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Abstract：
UNASSIGNED: This study aims to investigate the potential significance of mean platelet volume (MPV) and platelet distribution width (PDW) in predicting surgical neonatal necrotizing enterocolitis (NEC) and establish the correlation between MPV/PDW levels and the severity/prognosis of NEC.
UNASSIGNED: A retrospective study was conducted on a cohort of 372 patients diagnosed with NEC. The patients were categorized into two groups based on whether they underwent surgical therapy. Univariate /multivariate analysis were employed to compare the MPV and PDW between the two groups. Moreover, patients in surgical group were categorized into multiple subgroups based on intraoperative findings and postoperative prognosis, and the levels of MPV and PDW were compared among these subgroups.
UNASSIGNED: Of the 372 patients, the operative group exhibited significantly higher levels of MPV and PDW than the nonoperative group (P < 0.05). Logistic regression analysis revealed that MPV (OR = 4.895, P < 0.001) and PDW (OR = 1.476, P < 0.001) independently associated with surgical NEC. The analysis of the receiver operating characteristic (ROC) curve revealed that the area under the curve (AUC) was 0.706 for MPV alone, with a cut-off value of 11.8 fL. Similarly, the AUC was 0.728 for PDW alone, with a cut-off value of 16%. However, when MPV and PDW were combined, the AUC increased to 0.906 for predicting surgical NEC. In accordance with the intraoperative findings, the levels of MPV and PDW were found to be higher in the large area necrosis group than in the partial or mild necrosis group (P < 0.01). Furthermore, the MPV and PDW values in the death group were significantly greater than those in the survival group (P =0.040, P =0.008).
UNASSIGNED: MPV and PDW may serve as potentially valuable indicators for determining the need for surgical intervention and predicting the prognosis of patients with NEC.
UNASSIGNED: A retrospective study was conducted on a cohort of 372 patients diagnosed with NEC. The patients were categorized into two groups based on whether they underwent surgical therapy. Univariate /multivariate analysis were employed to compare the MPV and PDW between the two groups. Moreover, patients in surgical group were categorized into multiple subgroups based on intraoperative findings and postoperative prognosis, and the levels of MPV and PDW were compared among these subgroups.
UNASSIGNED: Of the 372 patients, the operative group exhibited significantly higher levels of MPV and PDW than the nonoperative group (P < 0.05). Logistic regression analysis revealed that MPV (OR = 4.895, P < 0.001) and PDW (OR = 1.476, P < 0.001) independently associated with surgical NEC. The analysis of the receiver operating characteristic (ROC) curve revealed that the area under the curve (AUC) was 0.706 for MPV alone, with a cut-off value of 11.8 fL. Similarly, the AUC was 0.728 for PDW alone, with a cut-off value of 16%. However, when MPV and PDW were combined, the AUC increased to 0.906 for predicting surgical NEC. In accordance with the intraoperative findings, the levels of MPV and PDW were found to be higher in the large area necrosis group than in the partial or mild necrosis group (P < 0.01). Furthermore, the MPV and PDW values in the death group were significantly greater than those in the survival group (P =0.040, P =0.008).
UNASSIGNED: MPV and PDW may serve as potentially valuable indicators for determining the need for surgical intervention and predicting the prognosis of patients with NEC.
摘要：
■本研究旨在探讨平均血小板体积（MPV）和血小板分布宽度（PDW）在预测新生儿坏死性小肠结肠炎（NEC）中的潜在意义，并建立MPV/PDW水平与NEC严重程度/预后的相关性。
■对372名诊断为NEC的患者进行了一项回顾性研究。根据患者是否接受手术治疗将患者分为两组。采用单因素/多因素分析比较两组间的MPV和PDW。此外，手术组患者根据术中发现和术后预后分为多个亚组，并比较这些亚组的MPV和PDW水平。
■在372名患者中,手术组的MPV和PDW水平明显高于非手术组（P<0.05）。Logistic回归分析显示MPV(OR=4.895,P<0.001)和PDW(OR=1.476,P<0.001)与手术NEC独立相关。受试者工作特征（ROC）曲线的分析显示，仅MPV的曲线下面积（AUC）为0.706，截止值为11.8fL。同样，仅PDW的AUC为0.728，截止值为16%。然而,当MPV和PDW组合时，预测手术NEC的AUC增加到0.906.根据术中发现,发现大面积坏死组的MPV和PDW水平高于部分或轻度坏死组（P<0.01）。此外，死亡组的MPV和PDW值均显著大于存活组(P=0.040,P=0.008).
■MPV和PDW可能作为确定是否需要手术干预和预测NEC患者预后的潜在有价值的指标。
■对372名诊断为NEC的患者进行了一项回顾性研究。根据患者是否接受手术治疗将患者分为两组。采用单因素/多因素分析比较两组间的MPV和PDW。此外，手术组患者根据术中发现和术后预后分为多个亚组，并比较这些亚组的MPV和PDW水平。
■在372名患者中,手术组的MPV和PDW水平明显高于非手术组（P<0.05）。Logistic回归分析显示MPV(OR=4.895,P<0.001)和PDW(OR=1.476,P<0.001)与手术NEC独立相关。受试者工作特征（ROC）曲线的分析显示，仅MPV的曲线下面积（AUC）为0.706，截止值为11.8fL。同样，仅PDW的AUC为0.728，截止值为16%。然而,当MPV和PDW组合时，预测手术NEC的AUC增加到0.906.根据术中发现,发现大面积坏死组的MPV和PDW水平高于部分或轻度坏死组（P<0.01）。此外，死亡组的MPV和PDW值均显著大于存活组(P=0.040,P=0.008).
■MPV和PDW可能作为确定是否需要手术干预和预测NEC患者预后的潜在有价值的指标。
