Abstract：
Objective To observe the expression of anti-β2 glycoprotein I (β2GPI) autoantibody in connective tissue diseases and its relationship with the degree of inflammation and immune function. Methods Patients with broad connective tissue diseases including connective tissue disease (CTD), rheumatoid arthritis (RA), Sjogren\'s syndrome (SS), and systemic lupus erythematosus (SLE) were observed. β2GPI was quantified by chemiluminescence, ESR was measured by Weil\'s method, and C-reactive protein (CRP), rheumatoid factor (RF), anti-cyclic citrullinated polypeptide (CCP) antibody were measured by automatic biochemical analyzer. Results β2GPI and their subtypes were significantly higher in RA patients compared with CTD, SS, and SLE patients. CRP was positively associated with anti-β2GPI antibody and anti-β2GPI antibody IgM in patients with connective tissue disease. ESR was positively associated with anti-β2GPI antibody. Anti-β2GPI antibody and anti-β2GPI antibody IgM were elevated in the abnormal CRP group compared with the normal CRP group. Compared with the ESR normal group, anti-β2GPI antibody and anti-β2GPI antibody IgG were elevated in the ESR abnormal group. Anti-β2GPI antibody was positively correlated with ESR and anti-CCP antibody in RA patients. Anti-β2GPI antibody IgG was positively correlated with RF. Conclusion β2GPI can be used as a predictor of the degree of inflammation and assessment of immune disorders in CTD.
摘要：
目的观察抗β2糖蛋白I(β2GPI)自身抗体在结缔组织疾病中的表达及其与炎症程度和免疫功能的关系。方法广泛的结缔组织病包括结缔组织病(CTD),类风湿性关节炎(RA),干燥综合征（SS），观察系统性红斑狼疮（SLE）。β2GPI通过化学发光定量，ESR用Weil法测量，和C反应蛋白（CRP），类风湿因子（RF），采用全自动生化分析仪测定抗环瓜氨酸多肽(CCP)抗体。结果RA患者的β2GPI及其亚型明显高于CTD,SS,SLE患者。结缔组织病患者CRP与抗β2GPI抗体、抗β2GPI抗体IgM呈正相关。ESR与抗β2GPI抗体呈正相关。CRP异常组抗β2GPI抗体和抗β2GPI抗体IgM较CRP正常组升高。与ESR正常组相比，ESR异常组抗β2GPI抗体和抗β2GPI抗体IgG升高。RA患者抗β2GPI抗体与ESR、抗CCP抗体呈正相关。抗β2GPI抗体IgG与RF呈正相关。结论β2GPI可作为CTD炎症程度的预测因子和免疫功能紊乱的评估指标。
