PDF(Pubmed)
Abstract：
The E-proteinoid 3 receptor (PTGER3), a member of the prostaglandin E2 (PGE2) subtype receptor, belongs to the G-protein-coupled superfamily of receptors. Animal studies have demonstrated its involvement in salt sensitivity by regulating sodium reabsorption. This study aimed to investigate the association between genetic variants of PTGER3 and salt sensitivity, longitudinal blood pressure (BP) changes, and the incidence of hypertension in Chinese adults. A chronic salt intake intervention was conducted involving 514 adults from 124 families in the 2004 Baoji Salt-Sensitivity Study Cohort in northern China. These participants followed a 3-day regular baseline diet, followed by a 7-day low-salt diet (3.0 g/d) and a 7-day high-salt diet (18 g/d), and were subsequently followed for 14 years. The findings revealed a significant relationship between the single nucleotide polymorphism (SNP) rs17482751 of PTGER3 and diastolic blood pressure (DBP) response to high salt intervention. Additionally, SNPs rs11209733, rs3765894, and rs2268062 were significantly associated with longitudinal changes in systolic blood pressure (SBP), DBP, and mean arterial pressure (MAP) during the 14-year follow-up period. SNP rs6424414 was significantly associated with longitudinal changes in DBP over 14 years. Finally, SNP rs17482751 showed a significant correlation with the incidence of hypertension over 14 years. These results emphasize the significant role of PTGER3 gene polymorphism in salt sensitivity, longitudinal BP changes, and the development of hypertension in the Chinese population.
摘要：
E蛋白3受体（PTGER3），前列腺素E2（PGE2）亚型受体的成员，属于受体的G蛋白偶联超家族。动物研究表明，它通过调节钠的重吸收而参与盐的敏感性。本研究旨在探讨PTGER3基因变异与盐敏感性的关系,纵向血压（BP）变化，和中国成年人高血压的发病率。在2004年中国北方宝鸡盐敏感性研究队列中，来自124个家庭的514名成年人进行了慢性盐摄入干预。这些参与者遵循3天的常规基线饮食，其次是7天的低盐饮食（3.0克/天）和7天的高盐饮食（18克/天），随后被跟踪了14年。发现发现PTGER3的单核苷酸多态性（SNP）rs17482751与高盐干预的舒张压（DBP）反应之间存在显着关系。此外,SNPsrs11209733，rs3765894和rs2268062与收缩压（SBP）的纵向变化显着相关，DBP,14年随访期间的平均动脉压（MAP）。SNPrs6424414与14年DBP的纵向变化显着相关。最后,SNPrs17482751与14年以上的高血压发病率有显著的相关性。这些结果强调了PTGER3基因多态性在盐敏感性中的重要作用。纵向BP变化，以及中国人群高血压的发展。
