PDF(Pubmed)
Abstract：
OBJECTIVE: Oral lichen planus carries a risk for malignancy. The pathogenesis of the disease is mediated by various inflammatory mediators. Several mediators could be responsible for the oncogenic behavior in certain cases. Hypoxia-inducible factor-1a (HIF-1), and its possible correlation to Galactin-3 (Gal-3) and matrix metalloproteinase-9 (MMP-9) over expression represents an important indicator for malignant transformation. The investigation of these factors may present evidence-based information on malignant transformation of the disease.
METHODS: The study investigated the expression of HIF-1, Gla-3 and MMP-9 in tissue samples of OLP compared to control subjects of un-inflamed gingival overgrowth. 20 biospecimen were allocated in each group.
RESULTS: Immunohistochemical findings of OLP showed immunoreactivity for Galectin 3, HIF1a and MMP-9 by most of the epithelial cells. There was a positive correlation between HIF1α and MMP-9, r = 0.9301 (P-value < 0.00001). A positive correlation was detected between Galectin 3 and MMP-9, r = 0.7292 (P-value = 0.000264) between Galectin 3 and HIF1α, r = 0.5893 (P-value = 0.006252).
CONCLUSIONS: These findings confirm the hypothesis that the adaptive pathways to hypoxia as Gal 3 and MMP-9 expressions and their HIF-1 may play a crucial role in carcinogenesis of OLP.
METHODS: The study investigated the expression of HIF-1, Gla-3 and MMP-9 in tissue samples of OLP compared to control subjects of un-inflamed gingival overgrowth. 20 biospecimen were allocated in each group.
RESULTS: Immunohistochemical findings of OLP showed immunoreactivity for Galectin 3, HIF1a and MMP-9 by most of the epithelial cells. There was a positive correlation between HIF1α and MMP-9, r = 0.9301 (P-value < 0.00001). A positive correlation was detected between Galectin 3 and MMP-9, r = 0.7292 (P-value = 0.000264) between Galectin 3 and HIF1α, r = 0.5893 (P-value = 0.006252).
CONCLUSIONS: These findings confirm the hypothesis that the adaptive pathways to hypoxia as Gal 3 and MMP-9 expressions and their HIF-1 may play a crucial role in carcinogenesis of OLP.
摘要：
目的：口腔扁平苔藓具有恶性肿瘤的风险。该疾病的发病机理是由各种炎症介质介导的。在某些情况下，几种介质可能是致癌行为的原因。缺氧诱导因子-1a(HIF-1),及其与Galactin-3（Gal-3）和基质金属蛋白酶-9（MMP-9）过表达的可能相关性是恶性转化的重要指标。对这些因素的调查可能会提供有关该疾病恶性转化的循证信息。
方法：该研究调查了与未发炎牙龈过度生长的对照受试者相比，OLP组织样品中HIF-1，Gla-3和MMP-9的表达。每组20份生物样本。
结果：OLP的免疫组织化学发现显示大多数上皮细胞对半乳糖凝集素3，HIF1a和MMP-9具有免疫反应性。HIF1α与MMP-9呈正相关,r=0.9301(P<0.00001)。半乳糖凝集素3与MMP-9呈正相关,半乳糖凝集素3与HIF1αr=0.7292(P值=0.000264)。r=0.5893(P值=0.006252)。
结论：这些发现证实了低氧的适应性途径Gal3和MMP-9的表达及其HIF-1可能在OLP的癌变中起关键作用。
方法：该研究调查了与未发炎牙龈过度生长的对照受试者相比，OLP组织样品中HIF-1，Gla-3和MMP-9的表达。每组20份生物样本。
结果：OLP的免疫组织化学发现显示大多数上皮细胞对半乳糖凝集素3，HIF1a和MMP-9具有免疫反应性。HIF1α与MMP-9呈正相关,r=0.9301(P<0.00001)。半乳糖凝集素3与MMP-9呈正相关,半乳糖凝集素3与HIF1αr=0.7292(P值=0.000264)。r=0.5893(P值=0.006252)。
结论：这些发现证实了低氧的适应性途径Gal3和MMP-9的表达及其HIF-1可能在OLP的癌变中起关键作用。
