%0 Journal Article
%T A critical influence of HIF-1 on MMP-9 and Galectin-3 in oral lichen planus.
%A Hazzaa HH
%A El Shiekh MAM
%A Elkashty O
%A Magdy E
%A Riad D
%A Khalifa E
%A Elewa GM
%A Kamal NM
%J BMC Oral Health
%V 24
%N 1
%D 2024 Jun 29
%M 38951854
%F 3.747
%R 10.1186/s12903-024-04457-6
%X <B>OBJECTIVE: </B>Oral lichen planus carries a risk for malignancy. The pathogenesis of the disease is mediated by various inflammatory mediators. Several mediators could be responsible for the oncogenic behavior in certain cases. Hypoxia-inducible factor-1a (HIF-1), and its possible correlation to Galactin-3 (Gal-3) and matrix metalloproteinase-9 (MMP-9) over expression represents an important indicator for malignant transformation. The investigation of these factors may present evidence-based information on malignant transformation of the disease.<BR><B>METHODS: </B>The study investigated the expression of HIF-1, Gla-3 and MMP-9 in tissue samples of OLP compared to control subjects of un-inflamed gingival overgrowth. 20 biospecimen were allocated in each group.<BR><B>RESULTS: </B>Immunohistochemical findings of OLP showed immunoreactivity for Galectin 3, HIF1a and MMP-9 by most of the epithelial cells. There was a positive correlation between HIF1α and MMP-9, r = 0.9301 (P-value < 0.00001). A positive correlation was detected between Galectin 3 and MMP-9, r = 0.7292 (P-value = 0.000264) between Galectin 3 and HIF1α, r = 0.5893 (P-value = 0.006252).<BR><B>CONCLUSIONS: </B>These findings confirm the hypothesis that the adaptive pathways to hypoxia as Gal 3 and MMP-9 expressions and their HIF-1 may play a crucial role in carcinogenesis of OLP.