METHODS: This study was based on the National Health and Nutrition Survey conducted between 2013 and 2016 and included 1024 adolescents whose median age was 15.4. Multivariate linear regression was used to examine the associations between HOMA-IR and PA and WWI. Using generalized additive models, a potential nonlinear link between WWI and HOMA-IR was evaluated. Subgroup analysis was also carried out.
RESULTS: The fully adjusted model revealed a positive association (β: 0.48, 95% CI: 0.43, 0.53) between the WWI and HOMA-IR. The HOMA-IR was lower in physically active (β: -0.16, 95% CI: -0.26, -0.05) participants versus inactive participants. Participants who had higher WWI and were not physically active (β: 0.69; 95% CI: 0.56, 0.82) had the highest levels of HOMA-IR compared to participants who had lower WWI and were physically active. Subgroup analysis revealed that these correlations were similar in males and females.
CONCLUSIONS: Our results demonstrated that higher WWI and PA were associated with a lower HOMA-IR and that WWI and PA had a combined association with HOMA-IR. The findings of this study are informative for the preventing insulin resistance in adolescents.
方法:这项研究基于2013年至2016年进行的全国健康和营养调查,包括1024名中位年龄为15.4岁的青少年。采用多元线性回归分析HOMA-IR与PA和WWI的相关性。使用广义加法模型,评估了WWI和HOMA-IR之间的潜在非线性联系。还进行了亚组分析。
结果:完全调整模型显示WWI和HOMA-IR之间存在正相关(β:0.48,95%CI:0.43,0.53)。与不活动参与者相比,身体活动参与者的HOMA-IR较低(β:-0.16,95%CI:-0.26,-0.05)。与WWI较低且身体活跃的参与者相比,WWI较高且身体不活跃的参与者(β:0.69;95%CI:0.56,0.82)的HOMA-IR水平最高。亚组分析显示,这些相关性在男性和女性中相似。
结论:我们的结果表明,较高的WWI和PA与较低的HOMA-IR相关,并且WWI和PA与HOMA-IR相关。这项研究的发现为预防青少年胰岛素抵抗提供了信息。