Abstract：
BACKGROUND: Vascular contributions to cognitive impairment and dementia (VCID) represent a major factor in cognitive decline in older adults. The present study examined the relationship between cerebrovascular reactivity (CVR) measured by magnetic resonance imaging (MRI) and cognitive function in a multi-site study, using a predefined hypothesis.
METHODS: We conducted the study in a total of three analysis sites and 263 subjects. Each site performed an identical CVR MRI procedure using 5% carbon dioxide inhalation. A global cognitive measure of Montreal Cognitive Assessment (MoCA) and an executive function measure of item response theory (IRT) score were used as outcomes.
RESULTS: CVR and MoCA were positively associated, and this relationship was reproduced at all analysis sites. CVR was found to be positively associated with executive function.
CONCLUSIONS: The predefined hypothesis on the association between CVR and a global cognitive score was validated in three independent analysis sites, providing support for CVR as a biomarker in VCID.
CONCLUSIONS: This study measured a novel functional index of small arteries referred to as cerebrovascular reactivity (CVR). CVR was positively associated with global cognition in older adults. This finding was observed in three independent cohorts at three sites. Our statistical analysis plan was predefined before beginning data collection.
METHODS: We conducted the study in a total of three analysis sites and 263 subjects. Each site performed an identical CVR MRI procedure using 5% carbon dioxide inhalation. A global cognitive measure of Montreal Cognitive Assessment (MoCA) and an executive function measure of item response theory (IRT) score were used as outcomes.
RESULTS: CVR and MoCA were positively associated, and this relationship was reproduced at all analysis sites. CVR was found to be positively associated with executive function.
CONCLUSIONS: The predefined hypothesis on the association between CVR and a global cognitive score was validated in three independent analysis sites, providing support for CVR as a biomarker in VCID.
CONCLUSIONS: This study measured a novel functional index of small arteries referred to as cerebrovascular reactivity (CVR). CVR was positively associated with global cognition in older adults. This finding was observed in three independent cohorts at three sites. Our statistical analysis plan was predefined before beginning data collection.
摘要：
背景：认知功能障碍和痴呆（VCID）的血管性贡献是老年人认知功能下降的主要因素。本研究检查了通过磁共振成像（MRI）测量的脑血管反应性（CVR）与认知功能之间的关系。使用预定义的假设。
方法：我们在总共三个分析点和263名受试者中进行了研究。每个部位使用5%二氧化碳吸入进行相同的CVRMRI程序。使用蒙特利尔认知评估（MoCA）的全球认知测量和项目反应理论（IRT）评分的执行功能测量作为结果。
结果：CVR和MoCA呈正相关，并且这种关系在所有分析站点都得到了复制.CVR与执行功能呈正相关。
结论：关于CVR与整体认知评分之间的关联的预定义假设在三个独立的分析站点得到了验证，为CVR作为VCID中的生物标志物提供支持。
结论：这项研究测量了小动脉的一种新功能指标，称为脑血管反应性（CVR）。CVR与老年人的整体认知呈正相关。这一发现在三个地点的三个独立队列中观察到。我们的统计分析计划是在开始数据收集之前预先定义的。
方法：我们在总共三个分析点和263名受试者中进行了研究。每个部位使用5%二氧化碳吸入进行相同的CVRMRI程序。使用蒙特利尔认知评估（MoCA）的全球认知测量和项目反应理论（IRT）评分的执行功能测量作为结果。
结果：CVR和MoCA呈正相关，并且这种关系在所有分析站点都得到了复制.CVR与执行功能呈正相关。
结论：关于CVR与整体认知评分之间的关联的预定义假设在三个独立的分析站点得到了验证，为CVR作为VCID中的生物标志物提供支持。
结论：这项研究测量了小动脉的一种新功能指标，称为脑血管反应性（CVR）。CVR与老年人的整体认知呈正相关。这一发现在三个地点的三个独立队列中观察到。我们的统计分析计划是在开始数据收集之前预先定义的。
