PDF(Pubmed)
Abstract：
To assess malnutrition contribution to the functional status and health related quality of life after hospitalization due to COVID-19 pneumonia, 66 selected adults referred for physical rehabilitation accepted to participate in the study; none of them required oxygen supply or had history of lung/musculoskeletal/neurological/immune/rheumatic disease or trauma, or contraindication for respiratory-function tests. At three evaluations, with 3 months in-between, assessments included: self-report of functional status, the St. George\'s Respiratory Questionnaire, spirometry, the 6-min-walk-test, the MRC-scale, the 30-s sit-to-stand-test, the timed-up-and-go-test, nutritional status, and ultrasound imaging (vastus medialis and diaphragm). At referral, patients had nutritional deficits with protein deficiency, which gradually improved; while muscle thickness (of both vastus medialis and diaphragm) increased, along with muscle strength and mobility (ANOVA, p < 0.05). Contrarywise, the distance covered during the 6-min-walk-test decreased (ANOVA, p < 0.05), with a negative influence from excess body mass. During rehabilitation, health-related quality of life and functional status improved, with negative influence from a history of tobacco use and referral delay, respectively. After hospitalization due to COVID-19, early diagnosis of both protein deficiency and decrease of skeletal muscle thickness could be relevant for rehabilitation, while pondering the negative impact of excess body mass on submaximal exercise performance.
摘要：
评估因COVID-19肺炎住院后营养不良对功能状态和健康相关生活质量的影响，接受参加本研究的66名接受身体康复的选定成年人；他们中没有人需要氧气供应或有肺/肌肉骨骼/神经/免疫/风湿性疾病或创伤史，或呼吸功能测试的禁忌症。在三次评估中，中间有3个月，评估包括：功能状态的自我报告，圣乔治呼吸问卷，肺活量测定,6分钟步行测试，MRC量表，30秒坐立测试，定时和通行测试，营养状况,和超声成像（股内侧肌和膈肌）。在转诊时，患者因蛋白质缺乏而营养不良，逐渐改善；而肌肉厚度（股纵肌和膈肌）增加，以及肌肉力量和活动能力(方差分析，p<0.05)。相反，在6分钟步行测试期间覆盖的距离减少(方差分析，p<0.05)，体重过重的负面影响。康复期间,与健康相关的生活质量和功能状态得到改善，由于烟草使用史和转诊延误的负面影响，分别。因COVID-19住院后，早期诊断蛋白质缺乏和骨骼肌厚度降低可能与康复有关，同时考虑体重过重对亚最大运动表现的负面影响。
