PDF(Pubmed)
Abstract：
Microglia are important players in surveillance and repair of the brain. Implanting an electrode into the cortex activates microglia, produces an inflammatory cascade, triggers the foreign body response, and opens the blood-brain barrier. These changes can impede intracortical brain-computer interfaces performance. Using two-photon imaging of implanted microelectrodes, we test the hypothesis that low-intensity pulsed ultrasound stimulation can reduce microglia-mediated neuroinflammation following the implantation of microelectrodes. In the first week of treatment, we found that low-intensity pulsed ultrasound stimulation increased microglia migration speed by 128%, enhanced microglia expansion area by 109%, and a reduction in microglial activation by 17%, indicating improved tissue healing and surveillance. Microglial coverage of the microelectrode was reduced by 50% and astrocytic scarring by 36% resulting in an increase in recording performance at chronic time. The data indicate that low-intensity pulsed ultrasound stimulation helps reduce the foreign body response around chronic intracortical microelectrodes.
摘要：
小胶质细胞是监测和修复大脑的重要参与者。将电极植入皮质会激活小胶质细胞，产生炎症级联反应，触发异物反应，打开血脑屏障.这些变化可能会阻碍皮质内脑-计算机接口的性能。使用植入的微电极的双光子成像，我们检验了低强度脉冲超声刺激可以减少微电极植入后小胶质细胞介导的神经炎症的假设.在治疗的第一周，我们发现低强度脉冲超声刺激使小胶质细胞迁移速度提高了128%,小胶质细胞扩张面积增加109%，小胶质细胞活化减少17%,表明改善组织愈合和监测。微电极的小胶质细胞覆盖率减少了50％，星形胶质细胞瘢痕形成减少了36％，从而导致了慢性记录性能的提高。数据表明，低强度脉冲超声刺激有助于减少慢性皮质内微电极周围的异物反应。
