Abstract：
OBJECTIVE: To describe the retinal and vitreous changes in eyes showing myopic macular schisis (MMS) improvement when vitrectomy was not performed and identify triggering factors.
METHODS: Retrospective observational study.
METHODS: Patients with nonoperated MMS.
METHODS: The records of patients with MMS who were followed without performing surgery for >6 months were retrospectively reviewed, and the eyes showing an anatomic improvement were included. Myopic macular schisis evolution was analyzed quantitatively (central foveal thickness [CFT], parafoveal thickness, maximum height) and qualitatively (presence/absence of foveal detachment, lamellar hole, epiretinal membrane, choroidal neovascularization, inner and outer retinoschisis, vitreous status) at baseline and at the final visit. An anatomic improvement was defined as a decrease in CFT by ≥50 μm.
METHODS: The rate of anatomic improvement of MMS without performing vitrectomy and the morphological changes observed in these cases.
RESULTS: In a cohort of 74 nonoperated eyes with MMS, MMS improved in 14 eyes (19%) after a mean follow-up of 55 ± 38 months (range, 8-138). In these improved cases, the mean decrease in CFT was 153 ± 166 μm (range, 24-635; P = 0.005) and a complete resolution of MMS was observed in 9 eyes (64%). In 9 eyes (64%), the improvement was associated with visible vitreous changes in the macular area on the OCT scans. The mean visual acuity, which was already good at baseline (20/50, 0.4 ± 0.2 logarithm of the minimum angle of resolution), increased at the last visit (20/40, 0.3 ± 0.3 logarithm of the minimum angle of resolution) but without reaching significance.
CONCLUSIONS: This long-term follow-up analysis showed that almost 20% of MMS in eyes without indication for surgery could improve over time. In most cases, the improvement was associated with an apparent resolution of vitreous tensions.
BACKGROUND: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
METHODS: Retrospective observational study.
METHODS: Patients with nonoperated MMS.
METHODS: The records of patients with MMS who were followed without performing surgery for >6 months were retrospectively reviewed, and the eyes showing an anatomic improvement were included. Myopic macular schisis evolution was analyzed quantitatively (central foveal thickness [CFT], parafoveal thickness, maximum height) and qualitatively (presence/absence of foveal detachment, lamellar hole, epiretinal membrane, choroidal neovascularization, inner and outer retinoschisis, vitreous status) at baseline and at the final visit. An anatomic improvement was defined as a decrease in CFT by ≥50 μm.
METHODS: The rate of anatomic improvement of MMS without performing vitrectomy and the morphological changes observed in these cases.
RESULTS: In a cohort of 74 nonoperated eyes with MMS, MMS improved in 14 eyes (19%) after a mean follow-up of 55 ± 38 months (range, 8-138). In these improved cases, the mean decrease in CFT was 153 ± 166 μm (range, 24-635; P = 0.005) and a complete resolution of MMS was observed in 9 eyes (64%). In 9 eyes (64%), the improvement was associated with visible vitreous changes in the macular area on the OCT scans. The mean visual acuity, which was already good at baseline (20/50, 0.4 ± 0.2 logarithm of the minimum angle of resolution), increased at the last visit (20/40, 0.3 ± 0.3 logarithm of the minimum angle of resolution) but without reaching significance.
CONCLUSIONS: This long-term follow-up analysis showed that almost 20% of MMS in eyes without indication for surgery could improve over time. In most cases, the improvement was associated with an apparent resolution of vitreous tensions.
BACKGROUND: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
摘要：
目的：描述未进行玻璃体切除术时显示近视黄斑裂开（MMS）改善的眼睛的视网膜和玻璃体变化，并确定触发因素。
方法：回顾性观察研究。
方法：非手术性近视性黄斑裂片患者方法：回顾性分析随访超过6个月未进行手术的MMS患者的记录，包括显示解剖学改善的眼睛。MMS演化进行了定量分析(中央凹厚度[CFT]，旁凹厚度，最大高度)和定性(存在/不存在中央凹脱离，层状孔，视网膜前膜,脉络膜新生血管,内外视网膜裂孔,玻璃体状态）在基线和最后一次访视时。解剖学改善定义为CFT降低至少50μm。
方法：在没有进行玻璃体切除术的情况下，MMS的解剖学改善率以及在这些病例中观察到的形态学变化。
结果：在74只患有彩信的非手术眼睛中，平均随访55±38个月后，MMS改善了14只眼（19％）（范围：8-138）。在这些改进的案例中，CFT的平均降低为153±166μm（范围：24-635，p=0.005），在9只眼中观察到MMS的完全分辨率（64％）。9只眼睛（64%）这种改善与OCT扫描中黄斑区可见的玻璃体变化有关.平均视力，在基线时已经很好（20/50，0.4±0.2LogMAR），末次访视时增加(20/40,0.3±0.3LogMAR),但未达到显著性。
结论：这项长期随访分析表明，无手术指征的眼睛中几乎20%的MMS可以随着时间的推移而改善。在大多数情况下,这种改善与玻璃体张力的明显消退有关.
方法：回顾性观察研究。
方法：非手术性近视性黄斑裂片患者方法：回顾性分析随访超过6个月未进行手术的MMS患者的记录，包括显示解剖学改善的眼睛。MMS演化进行了定量分析(中央凹厚度[CFT]，旁凹厚度，最大高度)和定性(存在/不存在中央凹脱离，层状孔，视网膜前膜,脉络膜新生血管,内外视网膜裂孔,玻璃体状态）在基线和最后一次访视时。解剖学改善定义为CFT降低至少50μm。
方法：在没有进行玻璃体切除术的情况下，MMS的解剖学改善率以及在这些病例中观察到的形态学变化。
结果：在74只患有彩信的非手术眼睛中，平均随访55±38个月后，MMS改善了14只眼（19％）（范围：8-138）。在这些改进的案例中，CFT的平均降低为153±166μm（范围：24-635，p=0.005），在9只眼中观察到MMS的完全分辨率（64％）。9只眼睛（64%）这种改善与OCT扫描中黄斑区可见的玻璃体变化有关.平均视力，在基线时已经很好（20/50，0.4±0.2LogMAR），末次访视时增加(20/40,0.3±0.3LogMAR),但未达到显著性。
结论：这项长期随访分析表明，无手术指征的眼睛中几乎20%的MMS可以随着时间的推移而改善。在大多数情况下,这种改善与玻璃体张力的明显消退有关.
