Abstract：
UNASSIGNED: We aim to estimate the odds of urinary tract infection (UTI)-related hospital care in spina bifida (SB) patients age 18 to 25 years as compared with patients with SB in adolescence (11-17 years) or adulthood (26-35 years). We hypothesize that patients with SB in the typical transitional age, 18 to 25 years, will have higher odds of UTI-related hospital care as compared to adolescent SB patients or adult SB patients.
UNASSIGNED: Using Cerner Real World Data, we performed a retrospective cohort analysis comparing SB patients to an age- and gender-matched controls. SB cases between 2015 and 2021 were identified and compared in 3 cohorts: 11 to 17 years (adolescents), 18 to 25 years (young adults [YA]), and 26 to 35 years (adults). Logistic regression analysis was used to characterize the odds of healthcare utilization.
UNASSIGNED: Of the 5497 patients with SB and 77,466 controls identified, 1839 SB patients (34%) and 3275 of controls (4.2%) had at least 1 UTI encounter. UTI-related encounters as a proportion of all encounters significantly increased with age in SB patients (adolescents 8%, YA 12%, adult 15%, P < .0001). Adjusting for race, sex, insurance and comorbidities, the odds of a UTI-related encounter in YA with SB was significantly higher than for adolescents with SB (adolescent OR = 0.65, 95% CI: 0.57-0.75, P < .001). YA had lower odds of a UTI-related encounter as compared with adults with SB (adult OR = 1.31, 95% CI: 1.16-1.49, P < .001).
UNASSIGNED: Young adults with SB have higher odds of UTI-related hospital care than adolescents, but lower odds of UTI-related hospital care when compared with adults.
UNASSIGNED: Using Cerner Real World Data, we performed a retrospective cohort analysis comparing SB patients to an age- and gender-matched controls. SB cases between 2015 and 2021 were identified and compared in 3 cohorts: 11 to 17 years (adolescents), 18 to 25 years (young adults [YA]), and 26 to 35 years (adults). Logistic regression analysis was used to characterize the odds of healthcare utilization.
UNASSIGNED: Of the 5497 patients with SB and 77,466 controls identified, 1839 SB patients (34%) and 3275 of controls (4.2%) had at least 1 UTI encounter. UTI-related encounters as a proportion of all encounters significantly increased with age in SB patients (adolescents 8%, YA 12%, adult 15%, P < .0001). Adjusting for race, sex, insurance and comorbidities, the odds of a UTI-related encounter in YA with SB was significantly higher than for adolescents with SB (adolescent OR = 0.65, 95% CI: 0.57-0.75, P < .001). YA had lower odds of a UTI-related encounter as compared with adults with SB (adult OR = 1.31, 95% CI: 1.16-1.49, P < .001).
UNASSIGNED: Young adults with SB have higher odds of UTI-related hospital care than adolescents, but lower odds of UTI-related hospital care when compared with adults.
摘要：
■我们的目的是评估18至25岁脊柱裂（SB）患者与青春期（11-17岁）或成年期（26-35岁）的SB患者发生尿路感染（UTI）相关医院护理的几率。我们假设SB患者在典型的过渡年龄，18到25年,与青少年SB患者或成年SB患者相比，接受UTI相关医院护理的几率更高。
■使用Cerner真实世界数据，我们进行了一项回顾性队列分析,比较了SB患者与年龄和性别匹配的对照.确定了2015年至2021年的SB病例，并在3个队列中进行了比较：11至17岁（青少年），18至25岁（年轻人[YA]），和26至35岁（成人）。使用Logistic回归分析来表征医疗保健利用的几率。
■在确定的5497名SB患者和77,466名对照患者中，1839例SB患者（34％）和3275例对照（4.2％）至少有1次UTI发作。在SB患者中，与UTI相关的遭遇占所有遭遇的比例随着年龄的增长而显着增加（青少年8％，YA12%，成人15%,P<.0001)。适应种族，性别,保险和合并症，在患有SB的YA患者中发生UTI相关遭遇的几率显著高于患有SB的青少年(青少年OR=0.65,95%CI:0.57-0.75,P<.001).与患有SB的成年人相比，YA与UTI相关的接触几率较低（成人OR=1.31，95％CI：1.16-1.49，P<.001）。
■与青少年相比，患有SB的年轻人接受与UTI相关的医院护理的几率更高，但与成人相比，UTI相关医院护理的可能性较低。
■使用Cerner真实世界数据，我们进行了一项回顾性队列分析,比较了SB患者与年龄和性别匹配的对照.确定了2015年至2021年的SB病例，并在3个队列中进行了比较：11至17岁（青少年），18至25岁（年轻人[YA]），和26至35岁（成人）。使用Logistic回归分析来表征医疗保健利用的几率。
■在确定的5497名SB患者和77,466名对照患者中，1839例SB患者（34％）和3275例对照（4.2％）至少有1次UTI发作。在SB患者中，与UTI相关的遭遇占所有遭遇的比例随着年龄的增长而显着增加（青少年8％，YA12%，成人15%,P<.0001)。适应种族，性别,保险和合并症，在患有SB的YA患者中发生UTI相关遭遇的几率显著高于患有SB的青少年(青少年OR=0.65,95%CI:0.57-0.75,P<.001).与患有SB的成年人相比，YA与UTI相关的接触几率较低（成人OR=1.31，95％CI：1.16-1.49，P<.001）。
■与青少年相比，患有SB的年轻人接受与UTI相关的医院护理的几率更高，但与成人相比，UTI相关医院护理的可能性较低。
