Abstract：
Going back in time through a phylogenetic tree makes it possible to evaluate ancestral genomes and assess their potential to acquire key polymorphisms of interest over evolutionary time. Knowledge of this kind may allow for the emergence of key traits to be predicted and pre-empted from currently circulating strains in the future. Here, we present a novel genome-wide survival analysis and use the emergence of drug resistance in Mycobacterium tuberculosis as an example to demonstrate the potential and utility of the technique.
摘要：
通过系统发育树回到过去，可以评估祖先基因组并评估其在进化时间内获得感兴趣的关键多态性的潜力。这种知识可能允许预测关键性状的出现，并在将来从当前流行的菌株中抢占。这里,我们提出了一种新的全基因组生存分析,并以结核分枝杆菌耐药性的出现为例,证明了该技术的潜力和实用性.
