Abstract：
UNASSIGNED: Acute Type A Aortic Dissection (AAAD) is one of the most life-threatening diseases, often associated with transient hyperglycemia induced by acute physiological stress. The impact of stress-induced hyperglycemia on the prognosis of ST-segment elevation myocardial infarction has been reported. However, the relationship between stress-induced hyperglycemia and the prognosis of AAAD patients remains uncertain.
UNASSIGNED: The clinical data of 456 patients with acute type A aortic dissection were retrospectively reviewed. Patients were divided into two groups based on their admission blood glucose. Cox model regression analysis was performed to assess the relationship between stress-induced hyperglycemia and the 30-day and 1-year mortality rates of these patients.
UNASSIGNED: Among the 456 patients, 149 cases (32.7%) had AAAD combined with stress-induced hyperglycemia (SIH). The results of the multifactor regression analysis of the Cox model indicated that hyperglycemia (RR = 1.505, 95% CI: 1.046-2.165, p = 0.028), aortic coarctation involving renal arteries (RR = 3.330, 95% CI: 2.237-4.957, p < 0.001), aortic coarctation involving superior mesenteric arteries (RR = 1.611, 95% CI: 1.056-2.455, p = 0.027), and aortic coarctation involving iliac arteries (RR = 2.034, 95% CI: 1.364-3.035, p = 0.001) were independent influences on 1-year postoperative mortality in AAAD patients.
UNASSIGNED: The current findings indicate that stress-induced hyperglycemia measured on admission is strongly associated with 1-year mortality in patients with AAAD. Furthermore, stress-induced hyperglycemia may be related to the severity of the condition in patients with AAAD.
UNASSIGNED: The clinical data of 456 patients with acute type A aortic dissection were retrospectively reviewed. Patients were divided into two groups based on their admission blood glucose. Cox model regression analysis was performed to assess the relationship between stress-induced hyperglycemia and the 30-day and 1-year mortality rates of these patients.
UNASSIGNED: Among the 456 patients, 149 cases (32.7%) had AAAD combined with stress-induced hyperglycemia (SIH). The results of the multifactor regression analysis of the Cox model indicated that hyperglycemia (RR = 1.505, 95% CI: 1.046-2.165, p = 0.028), aortic coarctation involving renal arteries (RR = 3.330, 95% CI: 2.237-4.957, p < 0.001), aortic coarctation involving superior mesenteric arteries (RR = 1.611, 95% CI: 1.056-2.455, p = 0.027), and aortic coarctation involving iliac arteries (RR = 2.034, 95% CI: 1.364-3.035, p = 0.001) were independent influences on 1-year postoperative mortality in AAAD patients.
UNASSIGNED: The current findings indicate that stress-induced hyperglycemia measured on admission is strongly associated with 1-year mortality in patients with AAAD. Furthermore, stress-induced hyperglycemia may be related to the severity of the condition in patients with AAAD.
摘要：
■急性A型主动脉夹层（AAAD）是最危及生命的疾病之一，常伴有急性生理应激引起的短暂性高血糖。应激性高血糖对ST段抬高型心肌梗死预后的影响已有报道。然而,应激性高血糖与AAAD患者预后的关系尚不明确.
■回顾性分析456例急性A型主动脉夹层患者的临床资料。根据入院血糖将患者分为两组。进行Cox模型回归分析以评估应激诱导的高血糖与这些患者的30天和1年死亡率之间的关系。
■在456名患者中，149例(32.7%)出现AAAD合并应激性高血糖(SIH)。Cox模型的多因素回归分析结果表明，高血糖（RR=1.505，95％CI：1.046-2.165，p=0.028），涉及肾动脉的主动脉缩窄（RR=3.330，95％CI：2.237-4.957，p<0.001），主动脉缩窄累及肠系膜上动脉(RR=1.611,95%CI:1.056-2.455,p=0.027),主动脉缩窄(RR=2.034,95%CI:1.364-3.035,p=0.001)是AAAD患者术后1年死亡率的独立影响因素。
■目前的研究结果表明，在AAAD患者中，入院时测得的应激性高血糖与1年死亡率密切相关。此外，应激性高血糖可能与AAAD患者病情的严重程度有关。
■回顾性分析456例急性A型主动脉夹层患者的临床资料。根据入院血糖将患者分为两组。进行Cox模型回归分析以评估应激诱导的高血糖与这些患者的30天和1年死亡率之间的关系。
■在456名患者中，149例(32.7%)出现AAAD合并应激性高血糖(SIH)。Cox模型的多因素回归分析结果表明，高血糖（RR=1.505，95％CI：1.046-2.165，p=0.028），涉及肾动脉的主动脉缩窄（RR=3.330，95％CI：2.237-4.957，p<0.001），主动脉缩窄累及肠系膜上动脉(RR=1.611,95%CI:1.056-2.455,p=0.027),主动脉缩窄(RR=2.034,95%CI:1.364-3.035,p=0.001)是AAAD患者术后1年死亡率的独立影响因素。
■目前的研究结果表明，在AAAD患者中，入院时测得的应激性高血糖与1年死亡率密切相关。此外，应激性高血糖可能与AAAD患者病情的严重程度有关。
