Abstract：
Three cyclic diarylheptanoids, myricanol (1), myricanone (2), and porson (3), were isolated from Myrica javanica (Myricaceae). As a major component, myricanol (1) was obtained from dry powdered bark and twigs (up to 1.6%). Transformation of myricanol (1) afforded 5-prenylmyricanol (4) and 5-benzylmyricanol (5) in 84.5% and 65% yields, respectively. The bioactivities of the isolated cyclic diarylheptanoids and their derivatives were investigated to determine their cytotoxicity and DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging activities. The cytotoxicity assay against murine leukaemia P-388 cells demonstrated that compounds 4 and 5 showed an almost two-fold increase in the activity of their parent molecule (1), with an IC50 value of 12 µM. Furthermore, the free radical scavenging assay showed that myricanol (1) had the highest radical scavenging activity, revealing the importance of the free phenolic group (IC50 39.3 µM).
摘要：
三环二芳基庚类，myricanol(1),Myricanone(2),和波森（3），从杨梅（Myricaceae）中分离。作为主要组成部分，从干粉树皮和树枝（高达1.6％）中获得肉豆蔻醇（1）。肉豆蔻醇（1）的转化以84.5％和65％的产率提供了5-戊烯基肉豆蔻醇（4）和5-苄基肉豆蔻醇（5）。分别。研究了分离的环状二芳基庚类化合物及其衍生物的生物活性，以确定其细胞毒性和DPPH（2,2-二苯基-1-吡啶酰肼）清除活性。针对小鼠白血病P-388细胞的细胞毒性测定表明，化合物4和5显示其母体分子的活性几乎增加了两倍（1），IC50值为12µM。此外，自由基清除实验表明，肉豆蔻醇(1)具有最高的自由基清除活性，揭示游离酚基的重要性（IC5039.3µM）。
