关键词: Chiroptera antiviral immunity immune cells immune genes immune molecules

Mesh : Chiroptera / virology immunology Animals Immunity, Innate Adaptive Immunity Humans Viruses / immunology classification Virus Diseases / immunology virology

来  源:   DOI:10.1002/jmv.29772

Abstract:
The distinct composition and immune response characteristics of bats\' innate and adaptive immune systems, which enable them to serve as host of numerous serious zoonotic viruses without falling ill, differ substantially from those of other mammals, it have garnered significant attention. In this article, we offer a systematic review of the names, attributes, and functions of innate and adaptive immune cells & molecules across different bat species. This includes descriptions of the differences shown by research between 71 bat species in 10 families, as well as comparisons between bats and other mammals. Studies of the immune cells & molecules of different bat species are necessary to understand the unique antiviral immunity of bats. By providing comprehensive information on these unique immune responses, it is hoped that new insights will be provided for the study of co-evolutionary dynamics between viruses and the bat immune system, as well as human antiviral immunity.
摘要:
蝙蝠先天和适应性免疫系统的独特组成和免疫反应特征,使它们能够作为许多严重的人畜共患病毒的宿主而不会生病,与其他哺乳动物有很大不同,它引起了极大的关注。在这篇文章中,我们对名字进行系统的审查,属性,以及不同蝙蝠物种的先天和适应性免疫细胞和分子的功能。这包括对10个科71种蝙蝠之间的研究差异的描述,以及蝙蝠和其他哺乳动物之间的比较。研究不同蝙蝠物种的免疫细胞和分子对于了解蝙蝠独特的抗病毒免疫力是必要的。通过提供有关这些独特免疫反应的全面信息,希望能为研究病毒和蝙蝠免疫系统之间的协同进化动力学提供新的见解,以及人类的抗病毒免疫力。
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