Abstract：
One new canthinone glycoside (1), together with six known compounds (2-7) including three lignans (2-4), two coumarins (5-6) and one phenol (7) was isolated from the root barks of Ailanthus altissima. The structure of new compound 1 was established by the interpretation of UV, IR, MS and NMR data, while its absolute configuration was determined by acid hydrolysis and GIAO NMR calculations with DP4+ probability analysis. The inhibitory effects of all compounds on Nitric oxide (NO) production were investigated in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Results showed that compounds 2 and 5 displayed NO production inhibitory activity with IC50 values of 30.1 and 15.3 μM, respectively.
摘要：
一种新的canthinone糖苷（1），连同六个已知的化合物（2-7），包括三个木脂素（2-4），从臭香根皮中分离出两种香豆素（5-6）和一种酚（7）。新化合物1的构造经由过程紫外解释，IR,MS和NMR数据，而其绝对构型是通过酸水解和GIAONMR计算以及DP4概率分析确定的。在脂多糖（LPS）诱导的RAW264.7细胞中研究了所有化合物对一氧化氮（NO）产生的抑制作用。结果表明，化合物2和5显示出NO产生抑制活性，IC50值分别为30.1和15.3μM。分别。
