{Reference Type}: Journal Article
{Title}: A new canthinone glycoside isolated from the root barks of Ailanthus altissima with NO inhibitory activity.
{Author}: Xue JF;Zhao CG;Pan H;Duan JJ;Jia YY;Chen H;Feng WS;Xue GM;
{Journal}: J Asian Nat Prod Res
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 1
{Factor}: 1.61
{DOI}: 10.1080/10286020.2024.2360047
{Abstract}: One new canthinone glycoside (1), together with six known compounds (2-7) including three lignans (2-4), two coumarins (5-6) and one phenol (7) was isolated from the root barks of Ailanthus altissima. The structure of new compound 1 was established by the interpretation of UV, IR, MS and NMR data, while its absolute configuration was determined by acid hydrolysis and GIAO NMR calculations with DP4+ probability analysis. The inhibitory effects of all compounds on Nitric oxide (NO) production were investigated in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Results showed that compounds 2 and 5 displayed NO production inhibitory activity with IC50 values of 30.1 and 15.3 μM, respectively.