UNASSIGNED: We performed a retrospective observational study in 134 hospitalized exacerbated COPD patients. 25-hydroxyvitamin D was modeled as a continuous or dichotomized (cutoff value: 10 or 20 ng/mL) variable to evaluate the association of SVDD with hospitalization in the previous year. Receiver operator characteristic (ROC) analysis was performed to find the optimal cut-off value of 25-hydroxyvitamin D.
UNASSIGNED: In total 23% of the patients had SVDD. SVDD was more prevalent in women, and SVDD group tended to have lower blood eosinophils counts. 25-hydroxyvitamin D level was significantly lower in patients who were hospitalized in the previous year (13.6 vs 16.7 ng/mL, P = 0.044), and the prevalence of SVDD was higher (38.0% vs 14.3%, P = 0.002). SVDD was independently associated with hospitalization in the previous year [odds ratio (OR) 4.34, 95% CI 1.61-11.72, P = 0.004] in hospitalized exacerbated COPD patients, whereas continuous 25-hydroxyvitamin D and VDD were not (P = 0.1, P = 0.9, separately). The ROC curve yielded an area under the curve of 0.60 (95% CI 0.50-0.71) with an optimal 25-hydroxyvitamin D cutoff of 10.4 ng/mL.
UNASSIGNED: SVDD probably showed a more stable association with hospitalization in the previous year in hospitalized exacerbated COPD patients. Reasons for lower eosinophil counts in SVDD group needed further exploration.
■我们在134例COPD加重住院患者中进行了一项回顾性观察研究。将25-羟基维生素D建模为连续或二分(截止值:10或20ng/mL)变量,以评估前一年SVDD与住院的关联。进行受试者工作特征(ROC)分析以找到25-羟基维生素D的最佳临界值。
■总共有23%的患者患有SVDD。SVDD在女性中更为普遍,和SVDD组倾向于有较低的血液嗜酸性粒细胞计数。前一年住院患者的25-羟基维生素D水平明显较低(13.6比16.7ng/mL,P=0.044),SVDD的患病率更高(38.0%vs14.3%,P=0.002)。在住院加重的COPD患者中,SVDD与前一年的住院独立相关[比值比(OR)4.34,95%CI1.61-11.72,P=0.004],而连续25-羟基维生素D和VDD则没有(P=0.1,P=0.9,分别)。ROC曲线的曲线下面积为0.60(95%CI0.50-0.71),最佳的25-羟基维生素D截止值为10.4ng/mL。
■在住院加重的COPD患者中,SVDD可能显示出与前一年住院更稳定的相关性。SVDD组嗜酸性粒细胞计数较低的原因需要进一步探索。