PDF(Pubmed)
Abstract：
UNASSIGNED: Given the established impact of exercise in reducing arterial stiffness and the potential for intermittent hypoxia to induce its elevation, this study aims to understand how oxygen desaturation during exercise affects arterial stiffness in individuals with COPD.
UNASSIGNED: We enrolled patients with stable COPD from China-Japan Friendship Hospital from November 2022 to June 2023. The 6-minute walk test (6-MWT) was performed with continuous blood oxygen saturation (SpO2) monitoring in these patients. The patients were classified into three groups: non-exercise induced desaturation (EID), mild-EID and severe-EID, according to the changes in SpO2 during the 6-MWT. The Cardio-Ankle Vascular Index (CAVI) and the change in CAVI (ΔCAVI, calculated as CAVI before 6MWT minus CAVI after the 6MWT) were measured before and immediately after the 6MWT to assess the acute effects of exercise on arterial stiffness. GOLD Stage, pulmonary function, and other functional outcomes were also measured in this study.
UNASSIGNED: A total of 37 patients with stable COPD underwent evaluation for changes in CAVI (ΔCAVI) before and after the 6-MWT. Stratification based on revealed three subgroups: non-EID (n=12), mild-EID (n=15), and severe-EID (n=10). The ΔCAVI values was -0.53 (-0.95 to -0.31) in non-EID group, -0.20 (-1.45 to 0.50) in mild-EID group, 0.6 (0.08 to 0.73) in severe-EID group. Parametric tests indicated significant differences in ΔCAVI among EID groups (p = 0.005). Pairwise comparisons demonstrated significant distinctions between mild-EID and severe-EID groups, as well as between non-EID and severe-EID groups (p = 0.048 and p = 0.003, respectively). Multivariable analysis, adjusting for age, sex, GOLD stage, diffusion capacity, and blood pressure, identified severe-EID as an independent factor associated with ΔCAVI (B = 1.118, p = 0.038).
UNASSIGNED: Patients with COPD and severe-EID may experience worsening arterial stiffness even during short periods of exercise.
UNASSIGNED: We enrolled patients with stable COPD from China-Japan Friendship Hospital from November 2022 to June 2023. The 6-minute walk test (6-MWT) was performed with continuous blood oxygen saturation (SpO2) monitoring in these patients. The patients were classified into three groups: non-exercise induced desaturation (EID), mild-EID and severe-EID, according to the changes in SpO2 during the 6-MWT. The Cardio-Ankle Vascular Index (CAVI) and the change in CAVI (ΔCAVI, calculated as CAVI before 6MWT minus CAVI after the 6MWT) were measured before and immediately after the 6MWT to assess the acute effects of exercise on arterial stiffness. GOLD Stage, pulmonary function, and other functional outcomes were also measured in this study.
UNASSIGNED: A total of 37 patients with stable COPD underwent evaluation for changes in CAVI (ΔCAVI) before and after the 6-MWT. Stratification based on revealed three subgroups: non-EID (n=12), mild-EID (n=15), and severe-EID (n=10). The ΔCAVI values was -0.53 (-0.95 to -0.31) in non-EID group, -0.20 (-1.45 to 0.50) in mild-EID group, 0.6 (0.08 to 0.73) in severe-EID group. Parametric tests indicated significant differences in ΔCAVI among EID groups (p = 0.005). Pairwise comparisons demonstrated significant distinctions between mild-EID and severe-EID groups, as well as between non-EID and severe-EID groups (p = 0.048 and p = 0.003, respectively). Multivariable analysis, adjusting for age, sex, GOLD stage, diffusion capacity, and blood pressure, identified severe-EID as an independent factor associated with ΔCAVI (B = 1.118, p = 0.038).
UNASSIGNED: Patients with COPD and severe-EID may experience worsening arterial stiffness even during short periods of exercise.
摘要：
■鉴于运动在降低动脉僵硬度方面的既定影响以及间歇性缺氧导致其升高的可能性，本研究旨在了解运动过程中氧饱和度降低对COPD患者动脉僵硬度的影响.
■我们于2022年11月至2023年6月在中日友好医院招募了稳定期COPD患者。在这些患者中进行6分钟步行测试（6-MWT），并进行连续血氧饱和度（SpO2）监测。患者分为三组：非运动诱导的去饱和（EID），轻度EID和重度EID，根据6-MWT期间SpO2的变化。心踝血管指数（CAVI）和CAVI的变化（ΔCAVI，计算为6MWT之前的CAVI减去6MWT之后的CAVI）在6MWT之前和之后立即进行测量，以评估运动对动脉僵硬度的急性影响。黄金舞台,肺功能,本研究还测量了其他功能结局.
■共有37例稳定期COPD患者接受了6-MWT前后CAVI（ΔCAVI）的变化评估。基于揭示的三个亚组的分层：非EID(n=12)，轻度EID（n=15），和严重EID（n=10）。非EID组的ΔCAVI值为-0.53（-0.95至-0.31），轻度EID组的-0.20（-1.45至0.50），重度EID组0.6（0.08至0.73）。参数测试表明EID组之间的ΔCAVI存在显着差异（p=0.005）。配对比较表明轻度EID和重度EID组之间存在显着差异，以及非EID和重度EID组之间（分别为p=0.048和p=0.003）。多变量分析，调整年龄，性别,黄金舞台,扩散能力，还有血压,确定重度EID是与ΔCAVI相关的独立因素(B=1.118，p=0.038)。
■患有COPD和严重EID的患者即使在短时间的运动中也可能经历动脉僵硬度恶化。
■我们于2022年11月至2023年6月在中日友好医院招募了稳定期COPD患者。在这些患者中进行6分钟步行测试（6-MWT），并进行连续血氧饱和度（SpO2）监测。患者分为三组：非运动诱导的去饱和（EID），轻度EID和重度EID，根据6-MWT期间SpO2的变化。心踝血管指数（CAVI）和CAVI的变化（ΔCAVI，计算为6MWT之前的CAVI减去6MWT之后的CAVI）在6MWT之前和之后立即进行测量，以评估运动对动脉僵硬度的急性影响。黄金舞台,肺功能,本研究还测量了其他功能结局.
■共有37例稳定期COPD患者接受了6-MWT前后CAVI（ΔCAVI）的变化评估。基于揭示的三个亚组的分层：非EID(n=12)，轻度EID（n=15），和严重EID（n=10）。非EID组的ΔCAVI值为-0.53（-0.95至-0.31），轻度EID组的-0.20（-1.45至0.50），重度EID组0.6（0.08至0.73）。参数测试表明EID组之间的ΔCAVI存在显着差异（p=0.005）。配对比较表明轻度EID和重度EID组之间存在显着差异，以及非EID和重度EID组之间（分别为p=0.048和p=0.003）。多变量分析，调整年龄，性别,黄金舞台,扩散能力，还有血压,确定重度EID是与ΔCAVI相关的独立因素(B=1.118，p=0.038)。
■患有COPD和严重EID的患者即使在短时间的运动中也可能经历动脉僵硬度恶化。
