PDF(Pubmed)
Abstract：
UNASSIGNED: To determine the association of urinary phthalate metabolites with chronic obstructive pulmonary disease (COPD), airflow obstruction, lung function and respiratory symptoms.
UNASSIGNED: Our study included a total of 2023 individuals aged ≥ 40 years old in the National Health and Nutrition Examination Survey (NHANES). Multivariate logistic regression was conducted to explore the correlation of eleven urinary phthalate metabolites (MCNP, MCOP, MECPP, MnBP, MCPP, MEP, MEHHP, MEHP, MiBP, MEOHP, and MBzP) with COPD, airflow obstruction and respiratory symptoms. Linear regression analyses were used to evaluate the relationship between urinary phthalate metabolites and lung function.
UNASSIGNED: When compared to the first tertile, the third tertile of MEHHP was associated with the risk of COPD [OR: 2.779; 95% confidence interval (CI): 1.129-6.840; P = 0.026]. Stratified analysis showed that MEHHP increased the risk of COPD by 7.080 times in male participants. Both MCPP and MBzP were positively correlated with the risk of airflow obstruction. The third tertile of MBzP increased the risk of cough by 1.545 (95% CI: 1.030-2.317; P = 0.035) times. Both FEV1 and FVC were negatively associated with MEHHP, MECPP, MnBP, MEP, MiBP and MEOHP.
UNASSIGNED: Higher levels of MEHHP are associated with increased risk of COPD, and lower measures of FEV1 and FVC. MBzP is positively related to airflow obstruction and cough.
UNASSIGNED: Our study included a total of 2023 individuals aged ≥ 40 years old in the National Health and Nutrition Examination Survey (NHANES). Multivariate logistic regression was conducted to explore the correlation of eleven urinary phthalate metabolites (MCNP, MCOP, MECPP, MnBP, MCPP, MEP, MEHHP, MEHP, MiBP, MEOHP, and MBzP) with COPD, airflow obstruction and respiratory symptoms. Linear regression analyses were used to evaluate the relationship between urinary phthalate metabolites and lung function.
UNASSIGNED: When compared to the first tertile, the third tertile of MEHHP was associated with the risk of COPD [OR: 2.779; 95% confidence interval (CI): 1.129-6.840; P = 0.026]. Stratified analysis showed that MEHHP increased the risk of COPD by 7.080 times in male participants. Both MCPP and MBzP were positively correlated with the risk of airflow obstruction. The third tertile of MBzP increased the risk of cough by 1.545 (95% CI: 1.030-2.317; P = 0.035) times. Both FEV1 and FVC were negatively associated with MEHHP, MECPP, MnBP, MEP, MiBP and MEOHP.
UNASSIGNED: Higher levels of MEHHP are associated with increased risk of COPD, and lower measures of FEV1 and FVC. MBzP is positively related to airflow obstruction and cough.
摘要：
■为了确定尿邻苯二甲酸盐代谢产物与慢性阻塞性肺疾病（COPD）的关系，气流阻塞,肺功能和呼吸道症状。
■我们的研究在国家健康和营养检查调查（NHANES）中纳入了2023名年龄≥40岁的个体。采用多因素logistic回归分析了11种尿邻苯二甲酸酯代谢物（MCNP，MCOP,MECPP,MnBP,MCPP,MEP,MEHHP,MEHP,MiBP,MEOHP,和MBzP）与COPD，气流阻塞和呼吸道症状。线性回归分析用于评估尿邻苯二甲酸酯代谢产物与肺功能之间的关系。
■与第一个三元字符相比，MEHHP的第三三分位数与COPD风险相关[OR:2.779;95%置信区间(CI):1.129~6.840;P=0.026].分层分析表明，MEHHP使男性参与者的COPD风险增加了7.080倍。MCPP和MBzP均与气流阻塞风险呈正相关。MBzP的第三三分位数增加了咳嗽的风险1.545（95％CI：1.030-2.317；P=0.035）倍。FEV1和FVC均与MEHHP呈负相关，MECPP,MnBP,MEP,MiBP和MEOHP。
■较高的MEHHP水平与COPD风险增加相关，FEV1和FVC的测量值较低。MBzP与气流阻塞和咳嗽呈正相干。
■我们的研究在国家健康和营养检查调查（NHANES）中纳入了2023名年龄≥40岁的个体。采用多因素logistic回归分析了11种尿邻苯二甲酸酯代谢物（MCNP，MCOP,MECPP,MnBP,MCPP,MEP,MEHHP,MEHP,MiBP,MEOHP,和MBzP）与COPD，气流阻塞和呼吸道症状。线性回归分析用于评估尿邻苯二甲酸酯代谢产物与肺功能之间的关系。
■与第一个三元字符相比，MEHHP的第三三分位数与COPD风险相关[OR:2.779;95%置信区间(CI):1.129~6.840;P=0.026].分层分析表明，MEHHP使男性参与者的COPD风险增加了7.080倍。MCPP和MBzP均与气流阻塞风险呈正相关。MBzP的第三三分位数增加了咳嗽的风险1.545（95％CI：1.030-2.317；P=0.035）倍。FEV1和FVC均与MEHHP呈负相关，MECPP,MnBP,MEP,MiBP和MEOHP。
■较高的MEHHP水平与COPD风险增加相关，FEV1和FVC的测量值较低。MBzP与气流阻塞和咳嗽呈正相干。
