PDF(Pubmed)
Abstract：
UNASSIGNED: Osteoarthritis (OA) is a common degenerative disorder of the synovial joints and is usually an age-related disease that occurs due to continuous wear and tear of the cartilage in the joints. Presently, there is no proven medical management to halt the progression of the disease in the early stages. The purpose of our systematic review is to analyze the possible metabolites and metabolic pathways that are specifically involved in OA pathogenesis and early treatment of the disease.
UNASSIGNED: The articles were collected from PubMed, Cochrane, Google Scholar, Embase, and Scopus databases. \"Knee\", \"Osteoarthritis\", \"Proteomics\", \"Lipidomics\", \"Metabolomics\", \"Metabolic Methods\", and metabolic* were employed for finding the articles. Only original articles with human or animal OA models with healthy controls were included.
UNASSIGNED: From the initial screening, a total of 458 articles were identified from the 5 research databases. From these, 297 articles were selected in the end for screening, of which 53 papers were selected for full-text screening. Finally, 50 articles were taken for the review based on body fluid: 6 urine studies, 15 plasma studies, 16 synovial fluid studies, 11 serum studies, 4 joint tissue studies, and 1 fecal study. Many metabolites were found to be elevated in OA. Some of these metabolites can be used to stage the OA Three pathways that were found to be commonly involved are the TCA cycle, the glycolytic pathway, and the lipid metabolism.
UNASSIGNED: All these studies showed a vast array of metabolites and metabolic pathways associated with OA. Metabolites like lysophospholipids, phospholipids, arginine, BCCA, and histidine were identified as potential biomarkers of OA but a definite association was not identified, Three pathways (glycolytic pathway, TCA cycle, and lipid metabolic pathways) have been found as highly significant in OA pathogenesis. These metabolic pathways could provide novel therapeutic targets for the prevention and progression of the disease.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s43465-024-01169-5.
UNASSIGNED: The articles were collected from PubMed, Cochrane, Google Scholar, Embase, and Scopus databases. \"Knee\", \"Osteoarthritis\", \"Proteomics\", \"Lipidomics\", \"Metabolomics\", \"Metabolic Methods\", and metabolic* were employed for finding the articles. Only original articles with human or animal OA models with healthy controls were included.
UNASSIGNED: From the initial screening, a total of 458 articles were identified from the 5 research databases. From these, 297 articles were selected in the end for screening, of which 53 papers were selected for full-text screening. Finally, 50 articles were taken for the review based on body fluid: 6 urine studies, 15 plasma studies, 16 synovial fluid studies, 11 serum studies, 4 joint tissue studies, and 1 fecal study. Many metabolites were found to be elevated in OA. Some of these metabolites can be used to stage the OA Three pathways that were found to be commonly involved are the TCA cycle, the glycolytic pathway, and the lipid metabolism.
UNASSIGNED: All these studies showed a vast array of metabolites and metabolic pathways associated with OA. Metabolites like lysophospholipids, phospholipids, arginine, BCCA, and histidine were identified as potential biomarkers of OA but a definite association was not identified, Three pathways (glycolytic pathway, TCA cycle, and lipid metabolic pathways) have been found as highly significant in OA pathogenesis. These metabolic pathways could provide novel therapeutic targets for the prevention and progression of the disease.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s43465-024-01169-5.
摘要：
■骨关节炎（OA）是滑膜关节的常见退行性疾病，通常是与年龄有关的疾病，由于关节中软骨的持续磨损而发生。目前,没有经过证实的医疗管理可以在早期阶段阻止疾病的进展。我们系统评价的目的是分析与OA发病机制和疾病早期治疗特异性相关的可能代谢产物和代谢途径。
■这些文章是从PubMed收集的，科克伦,谷歌学者，Embase,和Scopus数据库。\"膝盖\",“骨关节炎”，“蛋白质组学”，“脂质组学”，“代谢组学”，“代谢方法”，和代谢*被用来寻找物品。仅包括具有健康对照的人或动物OA模型的原始文章。
■从最初的筛选来看，从5个研究数据库中总共鉴定出458篇文章.从这些,最终筛选出297篇文章进行筛选，其中选择了53篇论文进行全文筛选。最后,50篇文章用于基于体液的审查：6项尿液研究，15血浆研究，16项滑液研究，11血清研究，4关节组织研究，和1个粪便研究。发现许多代谢物在OA中升高。这些代谢物中的一些可用于阶段OA。发现通常涉及的三种途径是TCA循环，糖酵解途径，和脂质代谢。
■所有这些研究显示了大量与OA相关的代谢产物和代谢途径。代谢产物如溶血磷脂，磷脂，精氨酸BCCA,和组氨酸被确定为OA的潜在生物标志物，但没有确定的关联，三种途径(糖酵解途径，TCA循环,和脂质代谢途径）已被发现在OA发病机理中非常重要。这些代谢途径可以为疾病的预防和进展提供新的治疗靶标。
■在线版本包含补充材料，可在10.1007/s43465-024-01169-5获得。
■这些文章是从PubMed收集的，科克伦,谷歌学者，Embase,和Scopus数据库。\"膝盖\",“骨关节炎”，“蛋白质组学”，“脂质组学”，“代谢组学”，“代谢方法”，和代谢*被用来寻找物品。仅包括具有健康对照的人或动物OA模型的原始文章。
■从最初的筛选来看，从5个研究数据库中总共鉴定出458篇文章.从这些,最终筛选出297篇文章进行筛选，其中选择了53篇论文进行全文筛选。最后,50篇文章用于基于体液的审查：6项尿液研究，15血浆研究，16项滑液研究，11血清研究，4关节组织研究，和1个粪便研究。发现许多代谢物在OA中升高。这些代谢物中的一些可用于阶段OA。发现通常涉及的三种途径是TCA循环，糖酵解途径，和脂质代谢。
■所有这些研究显示了大量与OA相关的代谢产物和代谢途径。代谢产物如溶血磷脂，磷脂，精氨酸BCCA,和组氨酸被确定为OA的潜在生物标志物，但没有确定的关联，三种途径(糖酵解途径，TCA循环,和脂质代谢途径）已被发现在OA发病机理中非常重要。这些代谢途径可以为疾病的预防和进展提供新的治疗靶标。
■在线版本包含补充材料，可在10.1007/s43465-024-01169-5获得。
