PDF(Pubmed)
Abstract：
UNASSIGNED: To investigate the effects of intraoperative intravenous administration of dexmedetomidine (DEX) on the recovery quality of donors undergoing pure laparoscopic donor hepatectomy.
UNASSIGNED: A total of 56 liver donors who were going to undergo scheduled pure laparoscopic donor hepatectomy were enrolled and randomly assigned to two groups, a DEX group ( n=28) and a control group ( n=28). Donors in the DEX group received DEX infusion at a dose of 1 μg/kg over 15 minutes through a continuous pump, which was followed by DEX at 0.4 μg/(kg·h) until the disconnection of the portal branch. Donors in the control group were given an equal volume of 0.9% normal saline at the same infusion rate and over the same period of time as those of the dex infusion in the DEX group. The primary outcome was the incidence of emergence agitation (EA). The Aono\'s Four-point Scale (AFPS) score was used to assess EA. The secondary observation indicators included intraoperative anesthesia and surgery conditions, spontaneous respiration recovery time, recovery time, extubation time, scores for the Ramsay Sedation Scale, the incidence of chills, numeric rating scale (NRS) score for pain, and blood pressure and heart rate after extubation.
UNASSIGNED: The incidence of EA was 10.7% and 39.3% in the DEX group and the control group, respectively, and the incidence of EA was significantly lower in the DEX group than that in the control group ( P=0.014). The APFS scores after extubation in the DEX group were lower than those in the control group (1 [1, 1] vs. 2 [1, 3], P=0.005). Compared to the control group, the dosages of intraoperative propofol and remifentanil were significantly reduced in the DEX group ( P<0.05). During the recovery period, the number of donors requiring additional boluses of analgesia, the blood pressure, and the heart rate were all lower in the DEX group than those in the control group ( P<0.05). No significant differences between the two groups were observed in the spontaneous respiration recovery time, recovery time, extubation time, the incidence of chills, NRS score, scores for the Ramsay Sedation Scale, and the length-of-stay in postanesthesia care unit (PACU) ( P>0.05).
UNASSIGNED: DEX can reduce the incidence of EA after pure laparoscopic donor hepatectomy and improve the quality of recovery without prolonging postoperative recovery time or extubation time.
UNASSIGNED: A total of 56 liver donors who were going to undergo scheduled pure laparoscopic donor hepatectomy were enrolled and randomly assigned to two groups, a DEX group ( n=28) and a control group ( n=28). Donors in the DEX group received DEX infusion at a dose of 1 μg/kg over 15 minutes through a continuous pump, which was followed by DEX at 0.4 μg/(kg·h) until the disconnection of the portal branch. Donors in the control group were given an equal volume of 0.9% normal saline at the same infusion rate and over the same period of time as those of the dex infusion in the DEX group. The primary outcome was the incidence of emergence agitation (EA). The Aono\'s Four-point Scale (AFPS) score was used to assess EA. The secondary observation indicators included intraoperative anesthesia and surgery conditions, spontaneous respiration recovery time, recovery time, extubation time, scores for the Ramsay Sedation Scale, the incidence of chills, numeric rating scale (NRS) score for pain, and blood pressure and heart rate after extubation.
UNASSIGNED: The incidence of EA was 10.7% and 39.3% in the DEX group and the control group, respectively, and the incidence of EA was significantly lower in the DEX group than that in the control group ( P=0.014). The APFS scores after extubation in the DEX group were lower than those in the control group (1 [1, 1] vs. 2 [1, 3], P=0.005). Compared to the control group, the dosages of intraoperative propofol and remifentanil were significantly reduced in the DEX group ( P<0.05). During the recovery period, the number of donors requiring additional boluses of analgesia, the blood pressure, and the heart rate were all lower in the DEX group than those in the control group ( P<0.05). No significant differences between the two groups were observed in the spontaneous respiration recovery time, recovery time, extubation time, the incidence of chills, NRS score, scores for the Ramsay Sedation Scale, and the length-of-stay in postanesthesia care unit (PACU) ( P>0.05).
UNASSIGNED: DEX can reduce the incidence of EA after pure laparoscopic donor hepatectomy and improve the quality of recovery without prolonging postoperative recovery time or extubation time.
摘要：
■探讨术中静脉给予右美托咪定（DEX）对单纯腹腔镜供肝切除术供者恢复质量的影响。
■共有56名拟接受预定纯腹腔镜肝切除术的肝脏捐献者入组，并随机分为两组，DEX组(n=28)和对照组(n=28)。DEX组的供体通过连续泵在15分钟内以1μg/kg的剂量接受DEX输注，随后以0.4μg/（kg·h）的速度进行DEX，直到门静脉分支断开。对照组的供体以与DEX组的dex输注相同的输注速率和相同的时间给予等体积的0.9％生理盐水。主要结果是出现躁动（EA）的发生率。Aono的四点量表（AFPS）评分用于评估EA。次要观察指标包括术中麻醉情况和手术情况,自主呼吸恢复时间，恢复时间,拔管时间,拉姆齐镇静量表的分数，发冷的发生率，疼痛数字评定量表(NRS)评分，拔管后的血压和心率。
■DEX组和对照组的EA发生率分别为10.7％和39.3％，分别,DEX组EA发生率明显低于对照组(P=0.014)。DEX组拔管后APFS评分低于对照组(1[1，1]vs.2[1,3],P=0.005)。与对照组相比,DEX组术中丙泊酚和瑞芬太尼的用量明显减少(P<0.05)。在恢复期间,需要额外镇痛药物的供体数量，血压,DEX组心率均低于对照组(P<0.05)。两组在自主呼吸恢复时间上无显著差异,恢复时间,拔管时间,发冷的发生率，NRS评分,拉姆齐镇静量表的分数，以及在麻醉后监护病房（PACU）的住院时间（P>0.05）。
■DEX可降低单纯腹腔镜供肝切除术后EA的发生率，提高恢复质量，而不延长术后恢复时间或拔管时间。
■共有56名拟接受预定纯腹腔镜肝切除术的肝脏捐献者入组，并随机分为两组，DEX组(n=28)和对照组(n=28)。DEX组的供体通过连续泵在15分钟内以1μg/kg的剂量接受DEX输注，随后以0.4μg/（kg·h）的速度进行DEX，直到门静脉分支断开。对照组的供体以与DEX组的dex输注相同的输注速率和相同的时间给予等体积的0.9％生理盐水。主要结果是出现躁动（EA）的发生率。Aono的四点量表（AFPS）评分用于评估EA。次要观察指标包括术中麻醉情况和手术情况,自主呼吸恢复时间，恢复时间,拔管时间,拉姆齐镇静量表的分数，发冷的发生率，疼痛数字评定量表(NRS)评分，拔管后的血压和心率。
■DEX组和对照组的EA发生率分别为10.7％和39.3％，分别,DEX组EA发生率明显低于对照组(P=0.014)。DEX组拔管后APFS评分低于对照组(1[1，1]vs.2[1,3],P=0.005)。与对照组相比,DEX组术中丙泊酚和瑞芬太尼的用量明显减少(P<0.05)。在恢复期间,需要额外镇痛药物的供体数量，血压,DEX组心率均低于对照组(P<0.05)。两组在自主呼吸恢复时间上无显著差异,恢复时间,拔管时间,发冷的发生率，NRS评分,拉姆齐镇静量表的分数，以及在麻醉后监护病房（PACU）的住院时间（P>0.05）。
■DEX可降低单纯腹腔镜供肝切除术后EA的发生率，提高恢复质量，而不延长术后恢复时间或拔管时间。
