PDF(Pubmed)
Abstract：
UNASSIGNED: Excessive gestational weight gain (GWG) is related to increased offspring fat accrual, and increased fat mass (FM) is related to obesity development. Prenatal DHA supplementation has been linked to lower levels of offspring FM; however, conflicting data exist.
UNASSIGNED: This study aimed to determine if there is a protective effect of prenatal DHA supplementation on offspring fat accrual and adipose tissue deposition at 24 mo in offspring born to females who gain excessive weight compared with nonexcessive weight during pregnancy. We also explored if the effect of DHA dose on FM differed by offspring sex.
UNASSIGNED: Infants born to females who participated in the Assessment of DHA on Reducing Early Preterm Birth randomized controlled trial (ADORE) were recruited. In ADORE, females were randomly assigned to either a high or low prenatal DHA supplement. Offspring body composition and adipose tissue distribution were measured using dual-energy x-ray absorptiometry (DXA). GWG was categorized as excessive or not excessive based on clinical guidelines.
UNASSIGNED: For total FM, there was a significant main effect for the DHA dose (P = 0.03); however, the dose by GWG status was nonsignificant (P = 0.44). Therefore, a higher prenatal DHA dose was related to greater offspring FM (622.9 g greater) and unrelated to GWG status. When investigating a DHA dose by sex effect, a significant main effect for DHA dose (P = 0.01) was detected for central FM. However, no interaction was detected (P = 0.98), meaning that both boys and girls had greater central FM if their mother was assigned to the higher DHA dose.
UNASSIGNED: Greater prenatal DHA supplementation was associated with greater offspring FM and adipose tissue distribution at 24 mo. It will be important to understand if these effects persist into childhood.This trial was registered at clinicaltrials.gov as NCT03310983.
UNASSIGNED: This study aimed to determine if there is a protective effect of prenatal DHA supplementation on offspring fat accrual and adipose tissue deposition at 24 mo in offspring born to females who gain excessive weight compared with nonexcessive weight during pregnancy. We also explored if the effect of DHA dose on FM differed by offspring sex.
UNASSIGNED: Infants born to females who participated in the Assessment of DHA on Reducing Early Preterm Birth randomized controlled trial (ADORE) were recruited. In ADORE, females were randomly assigned to either a high or low prenatal DHA supplement. Offspring body composition and adipose tissue distribution were measured using dual-energy x-ray absorptiometry (DXA). GWG was categorized as excessive or not excessive based on clinical guidelines.
UNASSIGNED: For total FM, there was a significant main effect for the DHA dose (P = 0.03); however, the dose by GWG status was nonsignificant (P = 0.44). Therefore, a higher prenatal DHA dose was related to greater offspring FM (622.9 g greater) and unrelated to GWG status. When investigating a DHA dose by sex effect, a significant main effect for DHA dose (P = 0.01) was detected for central FM. However, no interaction was detected (P = 0.98), meaning that both boys and girls had greater central FM if their mother was assigned to the higher DHA dose.
UNASSIGNED: Greater prenatal DHA supplementation was associated with greater offspring FM and adipose tissue distribution at 24 mo. It will be important to understand if these effects persist into childhood.This trial was registered at clinicaltrials.gov as NCT03310983.
摘要：
■妊娠期体重增加过多（GWG）与后代脂肪积累增加有关，脂肪量（FM）增加与肥胖的发展有关。产前补充DHA与较低水平的后代FM有关；然而，存在冲突的数据。
■本研究旨在确定产前补充DHA对24个月时后代脂肪积累和脂肪组织沉积的保护作用，这些后代与怀孕期间体重过重的雌性相比体重过重。我们还探讨了DHA剂量对FM的影响是否因后代性别而异。
■招募参与DHA降低早期早产随机对照试验（ADORE）的女性所生的婴儿。在ADORE,女性被随机分配到高或低的产前DHA补充剂。使用双能X射线吸收法（DXA）测量后代的身体组成和脂肪组织分布。根据临床指南，GWG被归类为过量或不过量。
■对于总FM，DHA剂量有显著的主效应(P=0.03)；然而，不同剂量的GWG状态无统计学意义(P=0.44).因此,更高的产前DHA剂量与更大的后代FM（更大622.9g）相关，与GWG状态无关。当按性别效应调查DHA剂量时，中心FM检测到DHA剂量的显着主要作用（P=0.01）。然而,未检测到相互作用(P=0.98)，这意味着，如果他们的母亲被分配到更高的DHA剂量，男孩和女孩都有更大的中央FM。
■在24个月时，更大的产前DHA补充与更大的后代FM和脂肪组织分布相关。重要的是要了解这些影响是否会持续到童年。该试验在clinicaltrials.gov注册为NCT03310983。
■本研究旨在确定产前补充DHA对24个月时后代脂肪积累和脂肪组织沉积的保护作用，这些后代与怀孕期间体重过重的雌性相比体重过重。我们还探讨了DHA剂量对FM的影响是否因后代性别而异。
■招募参与DHA降低早期早产随机对照试验（ADORE）的女性所生的婴儿。在ADORE,女性被随机分配到高或低的产前DHA补充剂。使用双能X射线吸收法（DXA）测量后代的身体组成和脂肪组织分布。根据临床指南，GWG被归类为过量或不过量。
■对于总FM，DHA剂量有显著的主效应(P=0.03)；然而，不同剂量的GWG状态无统计学意义(P=0.44).因此,更高的产前DHA剂量与更大的后代FM（更大622.9g）相关，与GWG状态无关。当按性别效应调查DHA剂量时，中心FM检测到DHA剂量的显着主要作用（P=0.01）。然而,未检测到相互作用(P=0.98)，这意味着，如果他们的母亲被分配到更高的DHA剂量，男孩和女孩都有更大的中央FM。
■在24个月时，更大的产前DHA补充与更大的后代FM和脂肪组织分布相关。重要的是要了解这些影响是否会持续到童年。该试验在clinicaltrials.gov注册为NCT03310983。
