PDF(Pubmed)
Abstract：
Recent advancements in biomedical research have underscored the importance of noninvasive cellular manipulation techniques. Sonogenetics, a method that uses genetic engineering to produce ultrasound-sensitive proteins in target cells, is gaining prominence along with optogenetics, electrogenetics, and magnetogenetics. Upon stimulation with ultrasound, these proteins trigger a cascade of cellular activities and functions. Unlike traditional ultrasound modalities, sonogenetics offers enhanced spatial selectivity, improving precision and safety in disease treatment. This technology broadens the scope of non-surgical interventions across a wide range of clinical research and therapeutic applications, including neuromodulation, oncologic treatments, stem cell therapy, and beyond. Although current literature predominantly emphasizes ultrasonic neuromodulation, this review offers a comprehensive exploration of sonogenetics. We discuss ultrasound properties, the specific ultrasound-sensitive proteins employed in sonogenetics, and the technique\'s potential in managing conditions such as neurological disorders, cancer, and ophthalmic diseases, and in stem cell therapies. Our objective is to stimulate fresh perspectives for further research in this promising field.
摘要：
生物医学研究的最新进展强调了非侵入性细胞操作技术的重要性。声遗传学,一种利用基因工程在靶细胞中产生超声敏感蛋白的方法，随着光遗传学越来越突出，电遗传学,和磁遗传学。用超声波刺激后，这些蛋白质引发细胞活动和功能的级联反应。与传统的超声模式不同，声遗传学提供了增强的空间选择性，提高疾病治疗的精度和安全性。这项技术在广泛的临床研究和治疗应用中拓宽了非手术干预的范围，包括神经调节，肿瘤治疗,干细胞疗法,和超越。尽管目前的文献主要强调超声神经调节，这篇综述提供了对超声遗传学的全面探索。我们讨论超声特性，超声遗传学中使用的特定超声敏感蛋白，以及该技术在管理神经系统疾病等疾病方面的潜力，癌症,和眼科疾病，和干细胞疗法。我们的目标是激发在这个有前途的领域进一步研究的新观点。
