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Abstract：
C-reactive protein (CRP) is a plasma protein that is evolutionarily conserved, found in both vertebrates and many invertebrates. It is a member of the pentraxin superfamily, characterized by its pentameric structure and calcium-dependent binding to ligands like phosphocholine (PC). In humans and various other species, the plasma concentration of this protein is markedly elevated during inflammatory conditions, establishing it as a prototypical acute phase protein that plays a role in innate immune responses. This feature can also be used clinically to evaluate the severity of inflammation in the organism. Human CRP (huCRP) can exhibit contrasting biological functions due to conformational transitions, while CRP in various species retains conserved protective functions in vivo. The focus of this review will be on the structural traits of CRP, the regulation of its expression, activate complement, and its function in related diseases in vivo.
摘要：
C反应蛋白（CRP）是一种进化保守的血浆蛋白，在脊椎动物和许多无脊椎动物中发现。它是pentraxin超家族的成员，其特征在于其五聚体结构和钙依赖性结合配体如磷酸胆碱(PC)。在人类和其他各种物种中，在炎症期间，这种蛋白质的血浆浓度显着升高，将其确立为在先天免疫反应中起作用的典型急性期蛋白。该特征还可以在临床上用于评估生物体中炎症的严重程度。人类CRP（huCRP）由于构象转变而表现出相反的生物学功能，而CRP在各种物种中保留了体内保守的保护功能。本文的重点是CRP的结构特征，其表达的调节，激活补体,及其在体内相关疾病中的作用。
