UNASSIGNED: Cross-sectional survey of a general population of 24,803 U.S. adults to determine the association of insomnia, poor sleep quality and sleep duration with PASC.
UNASSIGNED: Prevalence rates of PASC among previously COVID-19 infected participants for three definitions of PASC were COPE (21.9%), NICE (38.9%) and RECOVER PASC Score (15.3%). PASC was associated with insomnia in all 3 models in fully adjusted models with adjusted odds ratios (aORs) and 95% confidence intervals (CI) ranging from 1.30 (95% CI: 1.11-1.52, p≤0.05, PASC Score) to 1.52 (95% CI: 1.34-1.71, p≤0.001, (NICE). Poor sleep quality was related to PASC in all models with aORs ranging from 1.77 (95% CI: 1.60-1.97, p≤0.001, NICE) to 2.00 (95% CI: 1.77-2.26, p≤0.001, COPE). Sleep <6 hours was associated with PASC with aORs between 1.59 (95% CI: 1.40-1.80, p≤0.001, PASC Score) to 1.70 (95% CI: 1.53-1.89, p≤0.001, COPE). Sleep ≥ 9 hours was not associated with PASC in any model. Although vaccination with COVID-19 booster decreased the likelihood of developing PASC, it did not attenuate associations between insomnia, poor sleep quality and short sleep duration with PASC in any of the models.
UNASSIGNED: Insomnia, poor sleep quality and short sleep duration are potential risk factors for PASC. Interventions to improve sleep may decrease the development of PASC.
■对24,803名美国成年人进行横断面调查,以确定失眠的关联,PASC睡眠质量和睡眠时间差。
■先前感染COVID-19的参与者中PASC的患病率为COPE(21.9%),好(38.9%)和恢复PASC评分(15.3%)。在所有3个完全调整模型中,PASC与失眠相关,调整比值比(aOR)和95%置信区间(CI)范围为1.30(95%CI:1.11-1.52,p≤0.05,PASC评分)至1.52(95%CI:1.34-1.71,p≤0.001,(NICE)。在所有模型中,睡眠质量差与PASC相关,aOR范围为1.77(95%CI:1.60-1.97,p≤0.001,NICE)至2.00(95%CI:1.77-2.26,p≤0.001,COPE)。睡眠<6小时与PASC相关,aOR介于1.59(95%CI:1.40-1.80,p≤0.001,PASC评分)至1.70(95%CI:1.53-1.89,p≤0.001,COPE)。睡眠>9小时在任何模型中都与PASC无关。尽管COVID-19加强免疫降低了发生PASC的可能性,它并没有减弱失眠之间的联系,任何型号的PASC睡眠质量差,睡眠时间短。
■失眠,睡眠质量差和睡眠时间短是PASC的潜在危险因素。改善睡眠的干预措施可能会减少PASC的发展。
■当前知识/研究理由:失眠,睡眠质量差,睡眠持续时间的极端与COVID-19感染的可能性更高。然而,缺乏与SARS-CoV-2感染(PASC)急性后遗症发展相关的证据。研究影响:结果表明失眠,睡眠质量差和睡眠时间<6小时与先前感染过COVID-19的人中PASC患病率增加相关。这些发现为采用干预措施改善睡眠作为减少PASC发展的手段提供了支持。