PDF(Pubmed)
Abstract：
UNASSIGNED: Insomnia, poor sleep quality and extremes of sleep duration are associated with COVID-19 infection. This study assessed whether these factors are related to Post-Acute Sequelae of SARS-CoV-2 infection (PASC).
UNASSIGNED: Cross-sectional survey of a general population of 24,803 U.S. adults to determine the association of insomnia, poor sleep quality and sleep duration with PASC.
UNASSIGNED: Prevalence rates of PASC among previously COVID-19 infected participants for three definitions of PASC were COPE (21.9%), NICE (38.9%) and RECOVER PASC Score (15.3%). PASC was associated with insomnia in all 3 models in fully adjusted models with adjusted odds ratios (aORs) and 95% confidence intervals (CI) ranging from 1.30 (95% CI: 1.11-1.52, p≤0.05, PASC Score) to 1.52 (95% CI: 1.34-1.71, p≤0.001, (NICE). Poor sleep quality was related to PASC in all models with aORs ranging from 1.77 (95% CI: 1.60-1.97, p≤0.001, NICE) to 2.00 (95% CI: 1.77-2.26, p≤0.001, COPE). Sleep <6 hours was associated with PASC with aORs between 1.59 (95% CI: 1.40-1.80, p≤0.001, PASC Score) to 1.70 (95% CI: 1.53-1.89, p≤0.001, COPE). Sleep ≥ 9 hours was not associated with PASC in any model. Although vaccination with COVID-19 booster decreased the likelihood of developing PASC, it did not attenuate associations between insomnia, poor sleep quality and short sleep duration with PASC in any of the models.
UNASSIGNED: Insomnia, poor sleep quality and short sleep duration are potential risk factors for PASC. Interventions to improve sleep may decrease the development of PASC.
UNASSIGNED: Cross-sectional survey of a general population of 24,803 U.S. adults to determine the association of insomnia, poor sleep quality and sleep duration with PASC.
UNASSIGNED: Prevalence rates of PASC among previously COVID-19 infected participants for three definitions of PASC were COPE (21.9%), NICE (38.9%) and RECOVER PASC Score (15.3%). PASC was associated with insomnia in all 3 models in fully adjusted models with adjusted odds ratios (aORs) and 95% confidence intervals (CI) ranging from 1.30 (95% CI: 1.11-1.52, p≤0.05, PASC Score) to 1.52 (95% CI: 1.34-1.71, p≤0.001, (NICE). Poor sleep quality was related to PASC in all models with aORs ranging from 1.77 (95% CI: 1.60-1.97, p≤0.001, NICE) to 2.00 (95% CI: 1.77-2.26, p≤0.001, COPE). Sleep <6 hours was associated with PASC with aORs between 1.59 (95% CI: 1.40-1.80, p≤0.001, PASC Score) to 1.70 (95% CI: 1.53-1.89, p≤0.001, COPE). Sleep ≥ 9 hours was not associated with PASC in any model. Although vaccination with COVID-19 booster decreased the likelihood of developing PASC, it did not attenuate associations between insomnia, poor sleep quality and short sleep duration with PASC in any of the models.
UNASSIGNED: Insomnia, poor sleep quality and short sleep duration are potential risk factors for PASC. Interventions to improve sleep may decrease the development of PASC.
摘要：
■失眠,睡眠质量差和睡眠持续时间过长与COVID-19感染有关。这项研究评估了这些因素是否与SARS-CoV-2感染（PASC）的急性后遗症有关。
■对24,803名美国成年人进行横断面调查，以确定失眠的关联，PASC睡眠质量和睡眠时间差。
■先前感染COVID-19的参与者中PASC的患病率为COPE（21.9％），好（38.9%）和恢复PASC评分（15.3%）。在所有3个完全调整模型中，PASC与失眠相关，调整比值比（aOR）和95％置信区间（CI）范围为1.30（95％CI：1.11-1.52，p≤0.05，PASC评分）至1.52（95％CI：1.34-1.71，p≤0.001，（NICE）。在所有模型中，睡眠质量差与PASC相关，aOR范围为1.77（95％CI：1.60-1.97，p≤0.001，NICE）至2.00（95％CI：1.77-2.26，p≤0.001，COPE）。睡眠<6小时与PASC相关，aOR介于1.59（95％CI：1.40-1.80，p≤0.001，PASC评分）至1.70（95％CI：1.53-1.89，p≤0.001，COPE）。睡眠>9小时在任何模型中都与PASC无关。尽管COVID-19加强免疫降低了发生PASC的可能性，它并没有减弱失眠之间的联系，任何型号的PASC睡眠质量差，睡眠时间短。
■失眠，睡眠质量差和睡眠时间短是PASC的潜在危险因素。改善睡眠的干预措施可能会减少PASC的发展。
■当前知识/研究理由：失眠，睡眠质量差,睡眠持续时间的极端与COVID-19感染的可能性更高。然而,缺乏与SARS-CoV-2感染（PASC）急性后遗症发展相关的证据。研究影响：结果表明失眠，睡眠质量差和睡眠时间<6小时与先前感染过COVID-19的人中PASC患病率增加相关。这些发现为采用干预措施改善睡眠作为减少PASC发展的手段提供了支持。
■对24,803名美国成年人进行横断面调查，以确定失眠的关联，PASC睡眠质量和睡眠时间差。
■先前感染COVID-19的参与者中PASC的患病率为COPE（21.9％），好（38.9%）和恢复PASC评分（15.3%）。在所有3个完全调整模型中，PASC与失眠相关，调整比值比（aOR）和95％置信区间（CI）范围为1.30（95％CI：1.11-1.52，p≤0.05，PASC评分）至1.52（95％CI：1.34-1.71，p≤0.001，（NICE）。在所有模型中，睡眠质量差与PASC相关，aOR范围为1.77（95％CI：1.60-1.97，p≤0.001，NICE）至2.00（95％CI：1.77-2.26，p≤0.001，COPE）。睡眠<6小时与PASC相关，aOR介于1.59（95％CI：1.40-1.80，p≤0.001，PASC评分）至1.70（95％CI：1.53-1.89，p≤0.001，COPE）。睡眠>9小时在任何模型中都与PASC无关。尽管COVID-19加强免疫降低了发生PASC的可能性，它并没有减弱失眠之间的联系，任何型号的PASC睡眠质量差，睡眠时间短。
■失眠，睡眠质量差和睡眠时间短是PASC的潜在危险因素。改善睡眠的干预措施可能会减少PASC的发展。
■当前知识/研究理由：失眠，睡眠质量差,睡眠持续时间的极端与COVID-19感染的可能性更高。然而,缺乏与SARS-CoV-2感染（PASC）急性后遗症发展相关的证据。研究影响：结果表明失眠，睡眠质量差和睡眠时间<6小时与先前感染过COVID-19的人中PASC患病率增加相关。这些发现为采用干预措施改善睡眠作为减少PASC发展的手段提供了支持。
