%0 Journal Article
%T Sleep and long COVID: Preexisting sleep issues and the risk of PASC in a large general population using 3 different model definitions.
%A Quan SF
%A Weaver MD
%A Czeisler MÉ
%A Barger LK
%A Booker LA
%A Howard ME
%A Jackson ML
%A Lane RI
%A McDonald CF
%A Ridgers A
%A Robbins R
%A Varma P
%A Wiley JF
%A Rajaratnam SMW
%A Czeisler CA
%J medRxiv
%V 0
%N 0
%D 2024 Jun 21
%M 38947041
暂无%R 10.1101/2024.06.20.24309263
%X <B>UNASSIGNED: </B>Insomnia, poor sleep quality and extremes of sleep duration are associated with COVID-19 infection. This study assessed whether these factors are related to Post-Acute Sequelae of SARS-CoV-2 infection (PASC).<BR><B>UNASSIGNED: </B>Cross-sectional survey of a general population of 24,803 U.S. adults to determine the association of insomnia, poor sleep quality and sleep duration with PASC.<BR><B>UNASSIGNED: </B>Prevalence rates of PASC among previously COVID-19 infected participants for three definitions of PASC were COPE (21.9%), NICE (38.9%) and RECOVER PASC Score (15.3%). PASC was associated with insomnia in all 3 models in fully adjusted models with adjusted odds ratios (aORs) and 95% confidence intervals (CI) ranging from 1.30 (95% CI: 1.11-1.52, p≤0.05, PASC Score) to 1.52 (95% CI: 1.34-1.71, p≤0.001, (NICE). Poor sleep quality was related to PASC in all models with aORs ranging from 1.77 (95% CI: 1.60-1.97, p≤0.001, NICE) to 2.00 (95% CI: 1.77-2.26, p≤0.001, COPE). Sleep <6 hours was associated with PASC with aORs between 1.59 (95% CI: 1.40-1.80, p≤0.001, PASC Score) to 1.70 (95% CI: 1.53-1.89, p≤0.001, COPE). Sleep ≥ 9 hours was not associated with PASC in any model. Although vaccination with COVID-19 booster decreased the likelihood of developing PASC, it did not attenuate associations between insomnia, poor sleep quality and short sleep duration with PASC in any of the models.<BR><B>UNASSIGNED: </B>Insomnia, poor sleep quality and short sleep duration are potential risk factors for PASC. Interventions to improve sleep may decrease the development of PASC.