PDF(Pubmed)
Abstract：
Among individuals living with psychotic disorders, social impairment is common, debilitating, and challenging to treat. While the roots of this impairment are undoubtedly complex, converging lines of evidence suggest that social motivation and pleasure (MAP) deficits play a key role. Yet most neuroimaging studies have focused on monetary rewards, precluding decisive inferences. Here we leveraged parallel social and monetary incentive delay fMRI paradigms to test whether blunted reactivity to social incentives in the ventral striatum-a key component of the distributed neural circuit mediating appetitive motivation and hedonic pleasure-is associated with more severe MAP symptoms in a transdiagnostic sample enriched for psychosis. To maximize ecological validity and translational relevance, we capitalized on naturalistic audiovisual clips of an established social partner expressing positive feedback. Although both paradigms robustly engaged the ventral striatum, only reactivity to social incentives was associated with clinician-rated MAP deficits. This association remained significant when controlling for other symptoms, binary diagnostic status, or ventral striatum reactivity to monetary incentives. Follow-up analyses suggested that this association predominantly reflects diminished striatal activation during the receipt of social reward. These observations provide a neurobiologically grounded framework for conceptualizing the social-anhedonia symptoms and social impairments that characterize many individuals living with psychotic disorders and underscore the need to establish targeted intervention strategies.
摘要：
在患有精神病的人中，社会损害是常见的，衰弱，和具有挑战性的治疗。虽然这种损害的根源无疑是复杂的，越来越多的证据表明，社会动机和快乐(MAP)缺陷起着关键作用。然而，大多数神经影像学研究都集中在金钱奖励上，排除决定性的推论。在这里，我们利用平行的社会和货币激励延迟功能磁共振成像范式来测试腹侧纹状体对社会激励的迟钝反应是否与更严重的MAP症状相关，腹侧纹状体是介导食欲动机和享乐的分布式神经回路的关键组成部分，在富含精神病的诊断样本中。为了最大限度地提高生态有效性和翻译相关性，我们利用了一个既定的社会伙伴表达积极反馈的自然主义视听片段。尽管两种范式都强烈地参与了腹侧纹状体，只有对社会激励的反应性与临床医师评估的MAP缺陷相关.当控制其他症状时，这种关联仍然很重要，二进制诊断状态，或腹侧纹状体对货币激励的反应性。后续分析表明，这种关联主要反映了在获得社会奖励期间纹状体激活的减少。这些观察结果为概念化社会快感缺失症状和社会损害提供了神经生物学基础框架，这些社会快感缺失症状和社会损害是许多患有精神病的个体的特征，并强调需要建立有针对性的干预策略。
