PDF(Pubmed)
Abstract：
Plant phenolics have been known for various biological activities. This study aims to extract and examine the presence of phenolics in Bao mango (Mangifera indica L. var.) peel ethanolic extract (MPE). Further, antioxidant, anti-diabetic (α-amylase, and α-glucosidase inhibitory activity), and anti- Alzheimer\'s disease (AD) (acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-secretase (BACE-1) inhibitory activity) efficacy of MPE were determined. The results indicated that mangiferin (8755.89 mg/ 100 g extract) was the major phenolic compound in MPE. An antioxidant mechanism revealed that MPE had a higher radical scavenging ability (4266.70 µmol TE/g extract) compared to reducing power (FRAP) or oxygen radical absorption capacity (ORAC). Further in-vitro enzyme inhibitory assay against diabetic and AD involved enzymes showed that MPE had stronger inhibitory action against an enzyme involved in diabetes compared to their standard drug (Acarbose) (P < 0.05). While a lower IC50 value was observed against AD-involved enzymes compared to their standard drug (donepezil) (P < 0.05). The results show that Thai Bao mango peel byproduct can be a potential source of nutraceuticals to lower diabetes and improve cognitive health.
摘要：
已知植物酚类具有多种生物活性。本研究旨在提取和检查宝芒果（MangiferaindicaL.var。)果皮乙醇提取物(MPE)。Further,抗氧化剂，抗糖尿病药(α-淀粉酶，和α-葡萄糖苷酶抑制活性)，和抗阿尔茨海默病（AD）（乙酰胆碱酯酶（AChE），丁酰胆碱酯酶(BChE),测定MPE的β-分泌酶(BACE-1)抑制活性)功效。结果表明，芒果苷（8755.89mg/100g提取物）是MPE中的主要酚类化合物。抗氧化机制表明，与还原力（FRAP）或氧自由基吸收能力（ORAC）相比，MPE具有更高的自由基清除能力（4266.70µmolTE/g提取物）。对糖尿病和AD相关酶的进一步体外酶抑制试验表明，与标准药物（阿卡波糖）相比，MPE对糖尿病相关酶具有更强的抑制作用（P<0.05）。而与它们的标准药物(多奈哌齐)相比,观察到对AD相关酶的IC50值较低(P<0.05)。结果表明，泰宝芒果果皮副产品可以成为降低糖尿病和改善认知健康的潜在营养保健品来源。
