Abstract：
UNASSIGNED: CLEC10A is a C-type lectin receptor that specifically marks the conventional dendritic cell subsets two and three (cDC2 and DC3). It has a unique recognition profile of glycan antigens, with terminal N-Acetylgalactosamine residues that are frequently present in the tumor microenvironment. Even though CLEC10A expression allows for precise targeting of cDC2 and DC3 for the treatment of cancer, CLEC10A signaling has also been associated with anti-inflammatory responses that would promote tumor growth.
UNASSIGNED: Here, we review the potential benefits and drawbacks of CLEC10A engagement in the tumor microenvironment. We discuss the CLEC10A-mediated effects in different cell types and incorporate the pleiotropic effects of IL-10, the main anti-inflammatory response upon CLEC10A binding.
UNASSIGNED: To translate this to a successful CLEC10A-mediated immunotherapy with limited tumor-promoting capacities, finding the right ligand presentation and adjuvant combination will be key.
UNASSIGNED: Here, we review the potential benefits and drawbacks of CLEC10A engagement in the tumor microenvironment. We discuss the CLEC10A-mediated effects in different cell types and incorporate the pleiotropic effects of IL-10, the main anti-inflammatory response upon CLEC10A binding.
UNASSIGNED: To translate this to a successful CLEC10A-mediated immunotherapy with limited tumor-promoting capacities, finding the right ligand presentation and adjuvant combination will be key.
摘要：
■CLEC10A是一种C型凝集素受体，可特异性标记常规树突状细胞亚群2和3（cDC2和DC3）。它具有独特的聚糖抗原识别谱，具有经常存在于肿瘤微环境中的末端N-乙酰半乳糖胺残基。尽管CLEC10A表达允许cDC2和DC3的精确靶向治疗癌症，CLEC10A信号传导还与将促进肿瘤生长的抗炎应答相关。
■这里，我们综述了CLEC10A参与肿瘤微环境的潜在利弊.我们讨论了CLEC10A在不同细胞类型中介导的作用，并结合了IL-10的多效性作用，IL-10是CLEC10A结合时的主要抗炎反应。
■为了将其转化为一种成功的CLEC10A介导的免疫疗法，其促进肿瘤的能力有限，找到正确的配体呈递和佐剂组合将是关键。
■这里，我们综述了CLEC10A参与肿瘤微环境的潜在利弊.我们讨论了CLEC10A在不同细胞类型中介导的作用，并结合了IL-10的多效性作用，IL-10是CLEC10A结合时的主要抗炎反应。
■为了将其转化为一种成功的CLEC10A介导的免疫疗法，其促进肿瘤的能力有限，找到正确的配体呈递和佐剂组合将是关键。
