Abstract：
Studies evaluating Cisplatin-induced nephrotoxicity in minorities are limited. We conducted a retrospective review of adult patients receiving cisplatin from 2019 to 2023 at an inner-city hospital. Renal indices were obtained at baseline and after cycles 1, 2, and 3 of Cisplatin. A total of 93 patients were included, 46% were male. Median age was 57 years. About 40% were Black, 13% White, and 42% Hispanic. About 54% were uninsured. About 16% of the patients developed AKI after cycle 1 of cisplatin, 5% after cycle 2%, and 17% after cycle 3. There was no statistically significant correlation between race, sex, BMI and development of cisplatin-induced AKI. Repeated measures ANOVA test indicated a statistically significant and cumulative rise in creatinine level following cisplatin therapy [Wilks\' Lambda = 0.003, F(1,26)=13.7, η2 = 0.44]. Our study in a minority, low socioeconomic population highlights the progressive kidney injury following each cycle of cisplatin therapy. Further studies targeting this specific population are warranted to develop tailored interventions.
摘要：
评估顺铂在少数民族中引起的肾毒性的研究有限。我们对2019年至2023年在市中心医院接受顺铂治疗的成年患者进行了回顾性研究。在基线和顺铂第1、2和3周期后获得肾脏指数。共纳入93例患者，46%为男性。年龄中位数为57岁。大约40%是黑人，13%白色,和42%的西班牙裔。大约54％的人没有保险。约16%的患者在顺铂1周期后发生AKI，5%循环后2%，和17%后的周期3。种族之间没有统计学上显著的相关性,性别,BMI与顺铂诱导的AKI的发生发展.重复测量ANOVA检验表明顺铂治疗后肌酐水平有统计学意义和累积性升高[Wilksλ=0.003,F(1,26)=13.7,η2=0.44]。我们在少数人的研究中，低社会经济人群突出了顺铂治疗每个周期后的进行性肾损伤.针对这一特定人群的进一步研究需要制定量身定制的干预措施。
