PDF(Pubmed)
Abstract：
OBJECTIVE: This scoping review presents the preclinical and clinical data on the effects of high-dose radiation therapy (RT) on bone structure and function.
METHODS: An extensive PubMed search was performed for the relevant questions. The data were then synthesized into a comprehensive summary of the available relevant in-vitro, preclinical and clinical literature.
RESULTS: In-vitro studies of high-dose RT on cell cultures show considerable damage in the viability and functional capacity of the primary cells of the bones; the osteoclasts, the osteoblasts, and the osteocytes. In-vivo animal models show that high-dose RT induces significant morphological changes to the bone, inhibits the ability of bone to repair damage, and increases the fragility of the bone. Clinical data show that there is an increasing risk over time of damage to the bone, such as fractures, after high-dose RT.
CONCLUSIONS: These findings suggest that there may be a limit to the safe dose for single-fraction RT, and the long-term consequences of high-dose RT for the patients must be considered.
METHODS: An extensive PubMed search was performed for the relevant questions. The data were then synthesized into a comprehensive summary of the available relevant in-vitro, preclinical and clinical literature.
RESULTS: In-vitro studies of high-dose RT on cell cultures show considerable damage in the viability and functional capacity of the primary cells of the bones; the osteoclasts, the osteoblasts, and the osteocytes. In-vivo animal models show that high-dose RT induces significant morphological changes to the bone, inhibits the ability of bone to repair damage, and increases the fragility of the bone. Clinical data show that there is an increasing risk over time of damage to the bone, such as fractures, after high-dose RT.
CONCLUSIONS: These findings suggest that there may be a limit to the safe dose for single-fraction RT, and the long-term consequences of high-dose RT for the patients must be considered.
摘要：
目的：本范围综述提供了有关高剂量放射治疗（RT）对骨结构和功能影响的临床前和临床数据。
方法：对相关问题进行了广泛的PubMed搜索。然后将数据合成为可用的相关体外综合总结，临床前和临床文献。
结果：高剂量RT对细胞培养物的体外研究表明，骨骼原代细胞的活力和功能能力受到相当大的损害；破骨细胞，成骨细胞，和骨细胞。体内动物模型表明，高剂量RT诱导骨的显著形态变化，抑制骨骼修复损伤的能力，增加骨头的脆性.临床数据表明，随着时间的推移，骨骼受损的风险越来越大，比如骨折，高剂量RT后。
结论：这些研究结果表明，单部分RT的安全剂量可能存在限制，必须考虑高剂量RT对患者的长期后果。
方法：对相关问题进行了广泛的PubMed搜索。然后将数据合成为可用的相关体外综合总结，临床前和临床文献。
结果：高剂量RT对细胞培养物的体外研究表明，骨骼原代细胞的活力和功能能力受到相当大的损害；破骨细胞，成骨细胞，和骨细胞。体内动物模型表明，高剂量RT诱导骨的显著形态变化，抑制骨骼修复损伤的能力，增加骨头的脆性.临床数据表明，随着时间的推移，骨骼受损的风险越来越大，比如骨折，高剂量RT后。
结论：这些研究结果表明，单部分RT的安全剂量可能存在限制，必须考虑高剂量RT对患者的长期后果。
