Abstract：
UNASSIGNED: Despite the widespread use of opioids to manage severe pain, its systemic administration results in side effects. Among the subcutaneous and transdermal drug delivery systems developed to deal with adverse effects, microneedles have drawn attention due to their rapid action, high drug bioavailability, and improved permeability. SUF is an effective injectable opioid for treating severe pain. In this study, we investigated the analgesic effects of SUF using dissolvable microneedles.
UNASSIGNED: SUF polymeric dissolvable microneedles were constructed through the mold casting method and characterized by SEM and FTIR analysis. Its mechanical strength was also investigated using a texture analyzer. Fluorescence microscopy was applied in vitro to measure the penetration depth of microneedle arrays. Irritation and microchannel closure time, drug release profile, and hemocompatibility test were conducted for the validation of microneedle efficiency. Hot plate test was also used to investigate the analgesic effect of microneedle in an animal model.
UNASSIGNED: Local administration of SUF via dissolving microneedles had an effective analgesic impact. One hour after administration, there was no significant difference between the subcutaneous and the microneedle groups, and the mechanical properties were within acceptable limits.
UNASSIGNED: Microneedling is an effective strategy in immediate pain relief compared to the traditional methods.
UNASSIGNED: SUF polymeric dissolvable microneedles were constructed through the mold casting method and characterized by SEM and FTIR analysis. Its mechanical strength was also investigated using a texture analyzer. Fluorescence microscopy was applied in vitro to measure the penetration depth of microneedle arrays. Irritation and microchannel closure time, drug release profile, and hemocompatibility test were conducted for the validation of microneedle efficiency. Hot plate test was also used to investigate the analgesic effect of microneedle in an animal model.
UNASSIGNED: Local administration of SUF via dissolving microneedles had an effective analgesic impact. One hour after administration, there was no significant difference between the subcutaneous and the microneedle groups, and the mechanical properties were within acceptable limits.
UNASSIGNED: Microneedling is an effective strategy in immediate pain relief compared to the traditional methods.
摘要：
■尽管阿片类药物广泛用于治疗严重疼痛，其全身给药导致副作用。在为应对不良反应而开发的皮下和透皮给药系统中，微针由于动作迅速而引起了人们的注意，高药物生物利用度，和改善的渗透性。SUF是用于治疗严重疼痛的有效的可注射阿片类药物。在这项研究中,我们使用可溶性微针研究了SUF的镇痛作用。
■SUF聚合物可溶性微针通过模具铸造方法构造，并通过SEM和FTIR分析表征。还使用质构分析仪研究了其机械强度。体外应用荧光显微术测量微针阵列的穿透深度。刺激和微通道关闭时间，药物释放概况，和血液相容性试验进行微针效率的验证。还使用热板测试来研究微针在动物模型中的镇痛作用。
■通过溶解微针局部施用SUF具有有效的镇痛作用。给药后一小时，皮下和微针组之间没有显着差异，和机械性能在可接受的范围内。
■与传统方法相比，Microneedling是立即缓解疼痛的有效策略。
■SUF聚合物可溶性微针通过模具铸造方法构造，并通过SEM和FTIR分析表征。还使用质构分析仪研究了其机械强度。体外应用荧光显微术测量微针阵列的穿透深度。刺激和微通道关闭时间，药物释放概况，和血液相容性试验进行微针效率的验证。还使用热板测试来研究微针在动物模型中的镇痛作用。
■通过溶解微针局部施用SUF具有有效的镇痛作用。给药后一小时，皮下和微针组之间没有显着差异，和机械性能在可接受的范围内。
■与传统方法相比，Microneedling是立即缓解疼痛的有效策略。
