Abstract：
Handwashing represents an important personal hygiene measure for preventing infection. Herein, we report the persistence of antibacterial and antiviral effects after handwashing with fatty acid salt-based hand soap. To this end, we developed a new in vitro test method to measure persistence, utilizing coacervation formed by anionic surfactants and cationic polymers to retain highly effective soap components against each bacterium and virus on the skin. Coacervation with fatty acid salts and poly diallyldimethylammonium chloride (PDADMAC) as a cationic polymer allowed the persistence of antibacterial and antiviral effects against E. coli, S. aureus, and influenza virus even 4 h after handwashing. Furthermore, we confirmed an increase in the number of residual components effective against each bacterium and virus on the skin. In summary, the current findings describe an effective approach for enhancing the protective effects of handwashing.
摘要：
洗手是预防感染的重要个人卫生措施。在这里，我们报道了用脂肪酸盐基洗手皂洗手后抗菌和抗病毒作用的持久性.为此,我们开发了一种新的体外测试方法来测量持久性，利用由阴离子表面活性剂和阳离子聚合物形成的凝聚保留针对皮肤上的每种细菌和病毒的高效肥皂成分。与脂肪酸盐和聚二烯丙基二甲基氯化铵（PDADMAC）作为阳离子聚合物的凝聚允许对大肠杆菌的抗菌和抗病毒作用的持久性，金黄色葡萄球菌，和流感病毒甚至4小时后洗手。此外，我们证实了对皮肤上每种细菌和病毒有效的残留成分数量的增加。总之,目前的发现描述了一种增强洗手保护作用的有效方法。
