Abstract：
Patients with cirrhosis and clinically significant portal hypertension are at high risk of developing bacterial infections (BIs) that are the most common trigger of acute decompensation and acute-on-chronic liver failure. Furthermore, after decompensation, the risk of developing BIs further increases in an ominous vicious circle. BIs may be subtle, and they should be ruled out in all patients at admission and in case of deterioration. Timely administration of adequate empirical antibiotics is the cornerstone of treatment. Herein, we reviewed current evidences about pathogenesis, clinical implications and management of BIs in patients with cirrhosis and portal hypertension.
摘要：
肝硬化和临床上显着的门静脉高压症患者发生细菌感染（BI）的风险很高，这是急性代偿失调和慢性急性肝衰竭的最常见触发因素。此外，代偿失调后,在不祥的恶性循环中，开发BI的风险进一步增加。BIs可能很微妙，所有患者入院时和病情恶化时都应排除。及时给予足够的经验性抗生素是治疗的基石。在这里，我们回顾了目前关于发病机制的证据，肝硬化和门脉高压患者BI的临床意义和管理。
