Abstract：
UNASSIGNED: Pruritus is an unpleasant sensation that creates the urge to scratch. In many chronic conditions, relentless pruritus and scratching perpetuates a vicious itch-scratch cycle. Uncontrolled itch can detrimentally affect quality of life and may lead to sleep disturbance, impaired concentration, financial burden, and psychological suffering. Recent strides have been made to develop guidelines and investigate new therapies to treat some of the most common severely pruritic conditions, however, a large group of diseases remains underrecognized and undertreated. The purpose of this article is to provide a comprehensive review of the challenges hindering the treatment of pruritus.
UNASSIGNED: An online search was performed using PubMed, Web of Science, Google Scholar, and ClinicalTrials.gov from 1994 to 2024. Included studies were summarized and assessed for quality and relevance in treating pruritus.
UNASSIGNED: Several barriers to treating pruritus emerged, including variable presentation, objective measurement of itch, and identifying therapeutic targets. Itch associated with autoimmune conditions, connective tissue diseases, genodermatoses, cutaneous T-cell lymphoma, and pruritus of unknown origin were among the etiologies with the greatest unmet needs.
UNASSIGNED: Treating pruritus poses many challenges and there are many itchy conditions that have no yet been addressed. There is an urgent need for large-scale controlled studies to investigate potential targets for these conditions and novel therapies.
UNASSIGNED: An online search was performed using PubMed, Web of Science, Google Scholar, and ClinicalTrials.gov from 1994 to 2024. Included studies were summarized and assessed for quality and relevance in treating pruritus.
UNASSIGNED: Several barriers to treating pruritus emerged, including variable presentation, objective measurement of itch, and identifying therapeutic targets. Itch associated with autoimmune conditions, connective tissue diseases, genodermatoses, cutaneous T-cell lymphoma, and pruritus of unknown origin were among the etiologies with the greatest unmet needs.
UNASSIGNED: Treating pruritus poses many challenges and there are many itchy conditions that have no yet been addressed. There is an urgent need for large-scale controlled studies to investigate potential targets for these conditions and novel therapies.
摘要：
■瘙痒是一种令人不快的感觉，会产生抓挠的冲动。在许多慢性疾病中，无情的瘙痒和抓挠延续了恶痒-抓挠周期。无法控制的瘙痒会对生活质量产生不利影响，并可能导致睡眠障碍。浓度受损,财政负担,和心理上的痛苦。最近在制定指南和研究治疗一些最常见的严重瘙痒疾病的新疗法方面取得了进展。然而,一大类疾病仍然没有得到充分的认识和治疗。本文的目的是全面回顾阻碍瘙痒治疗的挑战。
■使用PubMed进行了在线搜索，WebofScience,谷歌学者，和ClinicalTrials.gov从1994年到2024年。对纳入的研究进行了总结，并评估了治疗瘙痒的质量和相关性。
■出现了治疗瘙痒的几个障碍，包括变量表示，客观测量瘙痒，并确定治疗目标。与自身免疫性疾病相关的瘙痒，结缔组织疾病,遗传性皮肤病，皮肤T细胞淋巴瘤,未知原因的瘙痒是最大的未满足需求的病因。
■治疗瘙痒带来了许多挑战，还有许多尚未解决的瘙痒状况。迫切需要大规模对照研究来研究这些病症和新疗法的潜在靶标。
■使用PubMed进行了在线搜索，WebofScience,谷歌学者，和ClinicalTrials.gov从1994年到2024年。对纳入的研究进行了总结，并评估了治疗瘙痒的质量和相关性。
■出现了治疗瘙痒的几个障碍，包括变量表示，客观测量瘙痒，并确定治疗目标。与自身免疫性疾病相关的瘙痒，结缔组织疾病,遗传性皮肤病，皮肤T细胞淋巴瘤,未知原因的瘙痒是最大的未满足需求的病因。
■治疗瘙痒带来了许多挑战，还有许多尚未解决的瘙痒状况。迫切需要大规模对照研究来研究这些病症和新疗法的潜在靶标。
