Abstract：
Basophils, rare granulocytes, have long been acknowledged for their roles in type 2 immune responses. However, the mechanisms by which basophils adapt their functions to diverse mammalian microenvironments remain unclear. Recent advancements in specific research tools and single-cell-based technologies have greatly enhanced our understanding of basophils. Several studies have shown that basophils play a role in maintaining homeostasis but can also contribute to pathology in various tissues and organs, including skin, lung, and others. Here, we provide an overview of recent basophil research, including cell development, characteristics, and functions. Based on an increasing understanding of basophil biology, we suggest that the precise targeting of basophil features might be beneficial in alleviating certain pathologies such as asthma, atopic dermatitis (AD), and others.
摘要：
嗜碱性粒细胞,稀有粒细胞,长期以来，它们在2型免疫反应中的作用被公认。然而,嗜碱性粒细胞使其功能适应不同哺乳动物微环境的机制尚不清楚.特定研究工具和基于单细胞的技术的最新进展极大地增强了我们对嗜碱性粒细胞的理解。一些研究表明，嗜碱性粒细胞在维持体内平衡中起作用，但也可以促进各种组织和器官的病理学。包括皮肤,肺，和其他人。这里,我们概述了最近的嗜碱性粒细胞研究，包括细胞发育，特点,和功能。基于对嗜碱性粒细胞生物学的日益理解，我们认为，精确靶向嗜碱性粒细胞特征可能有助于缓解某些病理，如哮喘，特应性皮炎(AD),和其他人。
