Abstract：
The discovery that metabolic alterations often coexist with neurodegenerative conditions has sparked interest in the examination of metabolic regulatory factors as potential modulators of brain health. Here, we examined the role of adipokines (leptin, adiponectin, resistin, and IL6) and insulin on different markers of brain atrophy in participants on the spectrum of Alzheimer\'s Disease. We included 566 participants from the Alzheimer\'s Disease Neuroimaging Initiative (ADNI) dataset with 1063 follow-up time points (average follow-up: one year); and examined the association between metabolic regulatory factors and volumetric MRI values, white matter hyperintensities, and measures of cognitive impairment. Higher leptin, resistin, IL6, and insulin were associated with markers of cerebral atrophy, such as lower total brain volume, or higher ventricular volume. Higher leptin and resistin were also associated with greater impairment in daily life activities. Higher adiponectin was associated with lower ventricle volume. There was no association between adipokines or insulin with white matter hyperintensities. Our findings indicate a co-occurrence between alterations in metabolic regulatory factors and in brain volume along the preclinical to clinical spectrum of Alzheimer\'s Disease. These results suggest that strategies aimed at promoting metabolic health may positively impact brain health.
摘要：
代谢改变通常与神经退行性疾病共存的发现引起了对代谢调节因子作为大脑健康潜在调节剂的检查的兴趣。这里,我们检查了脂肪因子(瘦素，脂联素,抵抗素,和IL6）和胰岛素对阿尔茨海默病频谱参与者脑萎缩的不同标记。我们纳入了来自阿尔茨海默病神经影像学倡议（ADNI）数据集的566名参与者，其中1063个随访时间点（平均随访时间：一年）；并检查了代谢调节因子与体积MRI值之间的关联。白质高强度，和认知障碍的测量。更高的瘦素，抵抗素,IL6和胰岛素与脑萎缩的标志物有关，如较低的大脑总体积，或更高的心室容积。较高的瘦素和抵抗素也与日常生活活动的更大损害有关。较高的脂联素与较低的心室容积有关。脂肪因子或胰岛素与白质高信号之间没有关联。我们的发现表明，在阿尔茨海默病的临床前至临床范围内，代谢调节因子和脑容量的变化之间存在共同发生。这些结果表明，旨在促进代谢健康的策略可能会对大脑健康产生积极影响。
