Abstract：
OBJECTIVE: We examined long-term outcomes of toxic shock syndrome.
METHODS: We conducted a matched cohort study of 630 patients with toxic shock syndrome and 5009 healthy controls between 2006 and 2021 in Quebec, Canada. Outcomes included hospitalization for renal, cardiovascular, hepatic, and other morbidity during 15 years of follow-up. We estimated adjusted hazard ratios (HR) and 95% confidence intervals (CI) for the risk of these outcomes over time, comparing patients with toxic shock syndrome relative to matched controls.
RESULTS: Compared with healthy controls, rehospitalization rates at 15 years were higher for men with toxic shock syndrome (52.0 vs 30.0 per 100) but not for women (38.7 vs 45.6 per 100). In men, toxic shock syndrome was associated with an elevated risk of renal (HR 17.43, 95% CI 6.35-47.82), cardiovascular (HR 2.57; 95% CI 1.52-4.34), and hepatic hospitalization (HR 19.83, 95% CI 4.72-83.34). In women, toxic shock syndrome was associated with renal hospitalization (HR 4.71, 95% CI 1.94-11.45). Streptococcal toxic shock was associated with a greater risk of rehospitalization than staphylococcal toxic shock.
CONCLUSIONS: Toxic shock syndrome is associated with rehospitalization up to 15 years later, especially in men. These patients may benefit from continued follow-up to prevent long-term morbidity.
METHODS: We conducted a matched cohort study of 630 patients with toxic shock syndrome and 5009 healthy controls between 2006 and 2021 in Quebec, Canada. Outcomes included hospitalization for renal, cardiovascular, hepatic, and other morbidity during 15 years of follow-up. We estimated adjusted hazard ratios (HR) and 95% confidence intervals (CI) for the risk of these outcomes over time, comparing patients with toxic shock syndrome relative to matched controls.
RESULTS: Compared with healthy controls, rehospitalization rates at 15 years were higher for men with toxic shock syndrome (52.0 vs 30.0 per 100) but not for women (38.7 vs 45.6 per 100). In men, toxic shock syndrome was associated with an elevated risk of renal (HR 17.43, 95% CI 6.35-47.82), cardiovascular (HR 2.57; 95% CI 1.52-4.34), and hepatic hospitalization (HR 19.83, 95% CI 4.72-83.34). In women, toxic shock syndrome was associated with renal hospitalization (HR 4.71, 95% CI 1.94-11.45). Streptococcal toxic shock was associated with a greater risk of rehospitalization than staphylococcal toxic shock.
CONCLUSIONS: Toxic shock syndrome is associated with rehospitalization up to 15 years later, especially in men. These patients may benefit from continued follow-up to prevent long-term morbidity.
摘要：
目的：我们检查了中毒性休克综合征的长期结局。
方法：我们在2006年至2021年间在魁北克对630名中毒性休克综合征患者和5,009名健康对照进行了配对队列研究，加拿大。结果包括肾脏住院，心血管,肝，和其他发病率在15年的随访。我们估计了随着时间的推移这些结果的风险的调整风险比（HR）和95％置信区间（CI）。比较中毒性休克综合征患者与匹配对照。
结果：与健康对照组相比，15岁时，中毒性休克综合征男性的再住院率较高(52.0vs30.0/100)，但不是女性（38.7比45.6每100）。在男人中，中毒性休克综合征与肾脏风险升高相关(HR17.43,95%CI6.35-47.82),心血管（HR2.57；95%CI1.52-4.34），和肝脏住院（HR19.83，95%CI4.72-83.34）。在女性中，中毒性休克综合征与肾脏住院相关(HR4.71,95%CI1.94~11.45).链球菌中毒性休克比葡萄球菌中毒性休克与更大的再住院风险相关。
结论：毒性休克综合征与15年后的再住院有关，尤其是男人。这些患者可能受益于持续的随访以防止长期发病。
方法：我们在2006年至2021年间在魁北克对630名中毒性休克综合征患者和5,009名健康对照进行了配对队列研究，加拿大。结果包括肾脏住院，心血管,肝，和其他发病率在15年的随访。我们估计了随着时间的推移这些结果的风险的调整风险比（HR）和95％置信区间（CI）。比较中毒性休克综合征患者与匹配对照。
结果：与健康对照组相比，15岁时，中毒性休克综合征男性的再住院率较高(52.0vs30.0/100)，但不是女性（38.7比45.6每100）。在男人中，中毒性休克综合征与肾脏风险升高相关(HR17.43,95%CI6.35-47.82),心血管（HR2.57；95%CI1.52-4.34），和肝脏住院（HR19.83，95%CI4.72-83.34）。在女性中，中毒性休克综合征与肾脏住院相关(HR4.71,95%CI1.94~11.45).链球菌中毒性休克比葡萄球菌中毒性休克与更大的再住院风险相关。
结论：毒性休克综合征与15年后的再住院有关，尤其是男人。这些患者可能受益于持续的随访以防止长期发病。
