Abstract：
BACKGROUND: Oral immunotherapy (OIT) has emerged as the most popular therapy for food allergy. However, data on the long-term adherence and efficacy of this approach are sparse.
OBJECTIVE: We aimed to assess the long-term adherence rates to OIT protocol and the associated risk of allergic reactions.
METHODS: Patients who completed milk OIT and reached a maintenance dose of 200 ml of milk were surveyed biannually on their dairy consumption and occurrence of allergic reactions. A survival analysis was performed to evaluate the association between the risk of reaction and adherence to OIT maintenance protocol.
RESULTS: The cohort consisted of 50 patients. Only 56% of the cohort adhered to protocol, which consisted of ingesting a minimum of 200 ml of milk at least 3 times per week. Adherent patients had a significantly reduced risk of allergic reactions, as well as a reduced incidence of anaphylaxis, healthcare/ER visits, and epinephrine/antihistamine administration.
CONCLUSIONS: The findings demonstrate the importance of consistent maintenance dose consumption in the management of food allergies, with regular milk consumption contributing to the maintenance of unresponsiveness and decreased risk of allergic symptoms.
OBJECTIVE: We aimed to assess the long-term adherence rates to OIT protocol and the associated risk of allergic reactions.
METHODS: Patients who completed milk OIT and reached a maintenance dose of 200 ml of milk were surveyed biannually on their dairy consumption and occurrence of allergic reactions. A survival analysis was performed to evaluate the association between the risk of reaction and adherence to OIT maintenance protocol.
RESULTS: The cohort consisted of 50 patients. Only 56% of the cohort adhered to protocol, which consisted of ingesting a minimum of 200 ml of milk at least 3 times per week. Adherent patients had a significantly reduced risk of allergic reactions, as well as a reduced incidence of anaphylaxis, healthcare/ER visits, and epinephrine/antihistamine administration.
CONCLUSIONS: The findings demonstrate the importance of consistent maintenance dose consumption in the management of food allergies, with regular milk consumption contributing to the maintenance of unresponsiveness and decreased risk of allergic symptoms.
摘要：
背景：口服免疫疗法（OIT）已成为最流行的食物过敏疗法。然而,关于这种方法的长期依从性和疗效的数据很少.
目的：我们旨在评估OIT方案的长期依从率和相关的过敏反应风险。
方法：完成牛奶OIT并达到200毫升牛奶维持剂量的患者，每半年对其乳制品消费量和过敏反应的发生情况进行调查。进行生存分析以评估反应风险与对OIT维持方案的依从性之间的关联。
结果：队列包括50名患者。只有56%的人遵守协议，包括每周至少摄入200毫升牛奶3次。粘附患者发生过敏反应的风险显着降低，以及减少过敏反应的发生率，医疗保健/急诊室就诊，和肾上腺素/抗组胺药。
结论：研究结果表明，持续的维持剂量消耗在食物过敏管理中的重要性，定期食用牛奶有助于维持反应迟钝，并降低过敏症状的风险。
目的：我们旨在评估OIT方案的长期依从率和相关的过敏反应风险。
方法：完成牛奶OIT并达到200毫升牛奶维持剂量的患者，每半年对其乳制品消费量和过敏反应的发生情况进行调查。进行生存分析以评估反应风险与对OIT维持方案的依从性之间的关联。
结果：队列包括50名患者。只有56%的人遵守协议，包括每周至少摄入200毫升牛奶3次。粘附患者发生过敏反应的风险显着降低，以及减少过敏反应的发生率，医疗保健/急诊室就诊，和肾上腺素/抗组胺药。
结论：研究结果表明，持续的维持剂量消耗在食物过敏管理中的重要性，定期食用牛奶有助于维持反应迟钝，并降低过敏症状的风险。
