{Reference Type}: Journal Article
{Title}: Long-term adherence and risk of allergic reactions in patients who attained milk oral immunotherapy maintenance.
{Author}: Mulé P;Zhang X;Prosty C;Beaudette L;Cohen CG;Chan E;Clarke AE;Grunebaum E;Ke D;Lejtenyi D;Lucchesi C;Mazer B;McCusker C;Upton J;Zhang L;Ben-Shoshan M;
{Journal}: J Allergy Clin Immunol Pract
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 27
暂无{DOI}: 10.1016/j.jaip.2024.06.031
{Abstract}: <B>BACKGROUND: </B>Oral immunotherapy (OIT) has emerged as the most popular therapy for food allergy. However, data on the long-term adherence and efficacy of this approach are sparse.<BR><B>OBJECTIVE: </B>We aimed to assess the long-term adherence rates to OIT protocol and the associated risk of allergic reactions.<BR><B>METHODS: </B>Patients who completed milk OIT and reached a maintenance dose of 200 ml of milk were surveyed biannually on their dairy consumption and occurrence of allergic reactions. A survival analysis was performed to evaluate the association between the risk of reaction and adherence to OIT maintenance protocol.<BR><B>RESULTS: </B>The cohort consisted of 50 patients. Only 56% of the cohort adhered to protocol, which consisted of ingesting a minimum of 200 ml of milk at least 3 times per week. Adherent patients had a significantly reduced risk of allergic reactions, as well as a reduced incidence of anaphylaxis, healthcare/ER visits, and epinephrine/antihistamine administration.<BR><B>CONCLUSIONS: </B>The findings demonstrate the importance of consistent maintenance dose consumption in the management of food allergies, with regular milk consumption contributing to the maintenance of unresponsiveness and decreased risk of allergic symptoms.