Abstract：
OBJECTIVE: This study aimed to investigate the correlation between genetic factors and the occurrence and progression of temporomandibular disorders (TMDs) using a comprehensive review and meta-analysis.
METHODS: A comprehensive search was conducted using the ScienceDirect, PubMed, Cochrane Library, Dimensions, and Emerald databases. A reviewer selected the study using modified PICO criteria, considering human subjects with TMDs, comparing different genetic factors among TMD and non-TMD patients, and reporting TMD signs and symptoms as outcomes. The methodological standards of the eligible papers were assessed using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Non-randomized Experimental Investigations. Information was collected methodically and examined.
RESULTS: The electronic database search yielded 851 articles, 19 of which were included in this study. The data analysis showed a significant influence of genetic factors, such as polymorphisms and gene differences, on the development of TMD signs and symptoms, such as myofascial pain, chronic pain, and disc displacement. In addition, gene polymorphism significantly influenced TMD development, with an odds ratio of 2.46 (1.93-3.14) and p of 0.00001.
CONCLUSIONS: Genetic factors significantly influenced TMD signs and symptoms, and genetic polymorphisms significantly influenced TMD onset and progression. Further research should be conducted in diverse settings with larger sample sizes to verify and validate these findings.
METHODS: A comprehensive search was conducted using the ScienceDirect, PubMed, Cochrane Library, Dimensions, and Emerald databases. A reviewer selected the study using modified PICO criteria, considering human subjects with TMDs, comparing different genetic factors among TMD and non-TMD patients, and reporting TMD signs and symptoms as outcomes. The methodological standards of the eligible papers were assessed using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Non-randomized Experimental Investigations. Information was collected methodically and examined.
RESULTS: The electronic database search yielded 851 articles, 19 of which were included in this study. The data analysis showed a significant influence of genetic factors, such as polymorphisms and gene differences, on the development of TMD signs and symptoms, such as myofascial pain, chronic pain, and disc displacement. In addition, gene polymorphism significantly influenced TMD development, with an odds ratio of 2.46 (1.93-3.14) and p of 0.00001.
CONCLUSIONS: Genetic factors significantly influenced TMD signs and symptoms, and genetic polymorphisms significantly influenced TMD onset and progression. Further research should be conducted in diverse settings with larger sample sizes to verify and validate these findings.
摘要：
目的：本研究旨在通过综合综述和荟萃分析，探讨遗传因素与颞下颌关节紊乱病（TMDs）发生和发展的相关性。
方法：使用ScienceDirect进行了全面搜索，PubMed,科克伦图书馆,尺寸,和翡翠数据库。审查人员使用修改后的PICO标准选择了这项研究，考虑到患有TMD的人类受试者，比较TMD和非TMD患者的不同遗传因素，并报告TMD体征和症状作为结果。使用JoannaBriggs研究所（JBI）非随机实验研究关键评估清单评估合格论文的方法学标准。信息是有条不紊地收集和检查的。
结果：电子数据库搜索产生了851篇文章，其中19个被纳入本研究。数据分析显示遗传因素的显著影响,如多态性和基因差异，关于TMD体征和症状的发展，如肌筋膜疼痛，慢性疼痛,和圆盘位移。此外,基因多态性显著影响TMD发育，比值比为2.46（1.93-3.14），p为0.00001。
结论：遗传因素显著影响TMD体征和症状，遗传多态性显著影响TMD的发病和进展。应在不同的环境中进行进一步的研究，以更大的样本量来验证和验证这些发现。
方法：使用ScienceDirect进行了全面搜索，PubMed,科克伦图书馆,尺寸,和翡翠数据库。审查人员使用修改后的PICO标准选择了这项研究，考虑到患有TMD的人类受试者，比较TMD和非TMD患者的不同遗传因素，并报告TMD体征和症状作为结果。使用JoannaBriggs研究所（JBI）非随机实验研究关键评估清单评估合格论文的方法学标准。信息是有条不紊地收集和检查的。
结果：电子数据库搜索产生了851篇文章，其中19个被纳入本研究。数据分析显示遗传因素的显著影响,如多态性和基因差异，关于TMD体征和症状的发展，如肌筋膜疼痛，慢性疼痛,和圆盘位移。此外,基因多态性显著影响TMD发育，比值比为2.46（1.93-3.14），p为0.00001。
结论：遗传因素显著影响TMD体征和症状，遗传多态性显著影响TMD的发病和进展。应在不同的环境中进行进一步的研究，以更大的样本量来验证和验证这些发现。
