Abstract：
The Mediator complex is an essential coregulator of RNA polymerase II transcription. More recent developments suggest Mediator functions as a link between transcription regulation, genome organisation and DNA repair mechanisms including nucleotide excision repair, base excision repair, and homologous recombination. Dysfunctions of these processes are frequently associated with human pathologies, and growing evidence shows Mediator involvement in cancers, neurological, metabolic and infectious diseases. The detailed deciphering of molecular mechanisms of Mediator functions, using interdisciplinary approaches in different biological models and considering all functions of this complex, will contribute to our understanding of relevant human diseases.
摘要：
介体复合物是RNA聚合酶II转录的必需共调节因子。最近的发展表明，介体功能是转录调控之间的联系，基因组组织和DNA修复机制，包括核苷酸切除修复，基底切除修复,和同源重组。这些过程的功能障碍通常与人类病理有关，越来越多的证据表明Mediator参与了癌症，神经学,代谢和传染病。介体功能的分子机制的详细破译，在不同的生物模型中使用跨学科的方法，并考虑到这个复合体的所有功能，将有助于我们对相关人类疾病的理解。
