PDF(Pubmed)
Abstract：
Background: Mistletoe is an herb that grows on duku plants (Lancium demosticum) and is known as benalu duku (BD) in Indonesia. It is predicted to have benefits such as anticancer or antiviral properties, and it is also thought to have anti-diabetic pharmacological activity. Quercetin-like compounds (QLCs) are secondary metabolites with antidiabetic activity that are expected to lower blood sugar levels in animals after oral administration.
Objective: This study aimed to analyze the ability of QLCs to reduce random blood sugar levels using experimental animals as clinical models.
Material and methods: The research method used was exploratory, which used a before-after test model, and observations were made on the random blood sugar levels after treatment. Secondary metabolites were extracted from BD leaves, which were then screened. Diabetes was induced in 30 rats (Rattus norvegicus) by the administration of streptozotocin at 0.045 mg/g body weight daily for 2 days. The antidiabetic effects of the secondary metabolite at doses of 0.5 mg/kg body weight (twice a day) when administered orally for up to 5 days were tested in diabetic rats. The random sugar levels (mg/dL) were measured using a One Touch Ultra Plus medical device for observation of randomized blood sugar levels. Results and novelty: The results revealed that the secondary metabolite, as an analyte from the BD leaf extract, can significantly reduce random blood sugar levels.
Conclusion: The secondary metabolite extracted from BD, could be used to treat diabetes in rats.
Objective: This study aimed to analyze the ability of QLCs to reduce random blood sugar levels using experimental animals as clinical models.
Material and methods: The research method used was exploratory, which used a before-after test model, and observations were made on the random blood sugar levels after treatment. Secondary metabolites were extracted from BD leaves, which were then screened. Diabetes was induced in 30 rats (Rattus norvegicus) by the administration of streptozotocin at 0.045 mg/g body weight daily for 2 days. The antidiabetic effects of the secondary metabolite at doses of 0.5 mg/kg body weight (twice a day) when administered orally for up to 5 days were tested in diabetic rats. The random sugar levels (mg/dL) were measured using a One Touch Ultra Plus medical device for observation of randomized blood sugar levels. Results and novelty: The results revealed that the secondary metabolite, as an analyte from the BD leaf extract, can significantly reduce random blood sugar levels.
Conclusion: The secondary metabolite extracted from BD, could be used to treat diabetes in rats.
摘要：
背景：槲寄生是一种生长在杜库植物（Lanciumdemosticum）上的草本植物，在印度尼西亚被称为benaluduku（BD）。预计它具有抗癌或抗病毒特性等益处，它也被认为具有抗糖尿病的药理活性。槲皮素类化合物(QLC)是具有抗糖尿病活性的次级代谢产物,其预期在口服给药后降低动物的血糖水平。
目的：本研究旨在使用实验动物作为临床模型分析QLC降低随机血糖水平的能力。
材料和方法：使用的研究方法是探索性的，使用了前后测试模型，并观察治疗后的随机血糖水平。从BD叶中提取次生代谢产物,然后进行筛选。通过每天以0.045mg/g体重施用链脲佐菌素2天，在30只大鼠（褐家鼠）中诱发了糖尿病。在糖尿病大鼠中测试了剂量为0.5mg/kg体重（每天两次）的次生代谢物的抗糖尿病作用。使用OneTouchUltraPlus医疗设备测量随机糖水平（mg/dL），以观察随机血糖水平。结果和新颖性：结果表明，次级代谢产物，作为BD叶提取物的分析物，能显著降低随机血糖水平。
结论：从BD中提取的次生代谢产物，可用于治疗大鼠糖尿病。
目的：本研究旨在使用实验动物作为临床模型分析QLC降低随机血糖水平的能力。
材料和方法：使用的研究方法是探索性的，使用了前后测试模型，并观察治疗后的随机血糖水平。从BD叶中提取次生代谢产物,然后进行筛选。通过每天以0.045mg/g体重施用链脲佐菌素2天，在30只大鼠（褐家鼠）中诱发了糖尿病。在糖尿病大鼠中测试了剂量为0.5mg/kg体重（每天两次）的次生代谢物的抗糖尿病作用。使用OneTouchUltraPlus医疗设备测量随机糖水平（mg/dL），以观察随机血糖水平。结果和新颖性：结果表明，次级代谢产物，作为BD叶提取物的分析物，能显著降低随机血糖水平。
结论：从BD中提取的次生代谢产物，可用于治疗大鼠糖尿病。
