PDF(Pubmed)
Abstract：
The Montreal Cognitive Assessment (MoCA) is a valuable assessment of the patient\'s awareness of time and place. We show that bacille Calmette-Guerin (BCG) significantly affects MoCA testing when administered by the intravesical route. MoCA scores were lower with increasing age and higher in more formally educated individuals. Patients receiving BCG tended to maintain their MoCA scores, whereas almost half the control cases tended to show reduced scores. This benefit is supported by reduced pre-amyloid biomarkers in BCG-injected healthy volunteers and a favorable effect on neuronal dendritic development in animal models. Our results suggest that BCG has a beneficial impact on the cognitive status of older individuals.
摘要：
蒙特利尔认知评估（MoCA）是对患者的时间和地点意识的有价值的评估。我们表明，通过膀胱内途径给药时，卡介苗（BCG）会显着影响MoCA测试。MoCA得分随着年龄的增长而降低，而受过正规教育的个体则更高。接受卡介苗的患者倾向于保持其MoCA评分，而几乎一半的对照病例倾向于显示得分降低。在注射BCG的健康志愿者中减少的前淀粉样蛋白生物标志物以及在动物模型中对神经元树突发育的有利作用支持了这种益处。我们的结果表明，卡介苗对老年人的认知状态有有益的影响。
