Abstract：
OBJECTIVE: COVID-19 has led to significant morbidity and mortality globally. Post-COVID sequelae can persist beyond the acute and subacute phases of infection, often termed Post-COVID Syndrome (PCS). There is limited evidence on the appropriate rehabilitation for people with PCS. The aim of this study is to evaluate the effect on exercise capacity, symptoms, cognition, anxiety, depression, health-related quality of life (HRQoL), and fatigue, of a 4-week, twice-weekly supervised pulmonary telerehabilitation program compared to usual medical care for people with PCS with persistent respiratory symptoms.
METHODS: The study will be a multi-site randomized controlled trial (RCT) with assessor blinding. Participants with confirmed previous COVID-19 infection and persistent respiratory symptoms who attend a post-COVID respiratory clinic will be randomized 1:1 to either an intervention group (IG) of 4 weeks, twice-weekly pulmonary telerehabilitation or a control group (CG) of usual medical care. Participants in the CG will be invited to cross-over into the IG after the week 4 assessment. Primary outcome: exercise capacity measured by the 1-minute sit-to-stand test. Secondary outcomes: 5 repetition sit-to-stand test; Montreal Cognitive Assessment; COVID-19 Yorkshire Rehabilitation Scale; COPD Assessment Test; 36-Item Short-Form Health Survey; Hospital Anxiety and Depression Scale; Fatigue Severity Scale; and the Kessler Psychological Distress Scale. Outcomes will be collected at baseline, after 4-weeks intervention or control period, after intervention in the cross-over group, and at 12-month follow-up.
UNASSIGNED: Research into effective rehabilitation programs is crucial given the substantial morbidity associated with PCS and the lack of long-term data for COVID-19 recovery. A short duration pulmonary telerehabilitation program, if effective compared to usual care, could inform practice guidelines and direct future clinical trials for the benefit of individuals with persistent respiratory symptoms post-COVID.
METHODS: The study will be a multi-site randomized controlled trial (RCT) with assessor blinding. Participants with confirmed previous COVID-19 infection and persistent respiratory symptoms who attend a post-COVID respiratory clinic will be randomized 1:1 to either an intervention group (IG) of 4 weeks, twice-weekly pulmonary telerehabilitation or a control group (CG) of usual medical care. Participants in the CG will be invited to cross-over into the IG after the week 4 assessment. Primary outcome: exercise capacity measured by the 1-minute sit-to-stand test. Secondary outcomes: 5 repetition sit-to-stand test; Montreal Cognitive Assessment; COVID-19 Yorkshire Rehabilitation Scale; COPD Assessment Test; 36-Item Short-Form Health Survey; Hospital Anxiety and Depression Scale; Fatigue Severity Scale; and the Kessler Psychological Distress Scale. Outcomes will be collected at baseline, after 4-weeks intervention or control period, after intervention in the cross-over group, and at 12-month follow-up.
UNASSIGNED: Research into effective rehabilitation programs is crucial given the substantial morbidity associated with PCS and the lack of long-term data for COVID-19 recovery. A short duration pulmonary telerehabilitation program, if effective compared to usual care, could inform practice guidelines and direct future clinical trials for the benefit of individuals with persistent respiratory symptoms post-COVID.
摘要：
目的：COVID-19在全球范围内导致了显著的发病率和死亡率。COVID后后遗症可持续超过急性和亚急性感染阶段，通常被称为后COVID综合征（PCS）。关于PCS患者的适当康复的证据有限。这项研究的目的是评估对运动能力的影响，症状,认知，焦虑,抑郁症,健康相关生活质量（HRQoL），和疲劳，4周,对于有持续呼吸道症状的PCS患者，与常规医疗相比，每周两次有监督的肺远程康复计划。
方法：该研究将是一项多站点随机对照试验（RCT），评估者致盲。确诊之前有COVID-19感染和持续呼吸道症状的参与者，参加COVID后呼吸道诊所，将被1：1随机分为4周的干预组(IG)，每周两次的肺部远程康复治疗或常规医疗的对照组（CG）。在第4周评估后，CG的参与者将被邀请跨入IG。主要结果：通过1分钟的坐立测试测量的运动能力。次要结果：5次重复坐姿测试；蒙特利尔认知评估；COVID-19约克郡康复量表；COPD评估测试；36项短期健康调查；医院焦虑和抑郁量表；疲劳严重程度量表；和凯斯勒心理困扰量表。结果将在基线时收集，经过4周的干预或控制期，在交叉组干预后，在12个月的随访中。
■鉴于与PCS相关的大量发病率以及缺乏COVID-19恢复的长期数据，研究有效的康复计划至关重要。短期肺远程康复计划，如果与常规护理相比有效，可以为实践指南提供信息，并指导未来的临床试验，以使患有COVID后持续呼吸道症状的个体受益。
方法：该研究将是一项多站点随机对照试验（RCT），评估者致盲。确诊之前有COVID-19感染和持续呼吸道症状的参与者，参加COVID后呼吸道诊所，将被1：1随机分为4周的干预组(IG)，每周两次的肺部远程康复治疗或常规医疗的对照组（CG）。在第4周评估后，CG的参与者将被邀请跨入IG。主要结果：通过1分钟的坐立测试测量的运动能力。次要结果：5次重复坐姿测试；蒙特利尔认知评估；COVID-19约克郡康复量表；COPD评估测试；36项短期健康调查；医院焦虑和抑郁量表；疲劳严重程度量表；和凯斯勒心理困扰量表。结果将在基线时收集，经过4周的干预或控制期，在交叉组干预后，在12个月的随访中。
■鉴于与PCS相关的大量发病率以及缺乏COVID-19恢复的长期数据，研究有效的康复计划至关重要。短期肺远程康复计划，如果与常规护理相比有效，可以为实践指南提供信息，并指导未来的临床试验，以使患有COVID后持续呼吸道症状的个体受益。
