Abstract：
BACKGROUND: Rhinoplasty is a common surgical procedure used in nose esthetics and pathologies. Shaping the nasal bones is a crucial step in achieving successful rhinoplasty surgery. However, complications such as excessive bleeding, edema, mucosal damage, and periosteal damage may occur during osteotomy for nose shaping.
OBJECTIVE: To investigate the damage to soft tissue and the effects on oxidative stress and proinflammatory cytokines in the blood caused by osteotomy performed on rabbits, using different osteotomy methods. Methods: Thirty-two albino New Zealand rabbits were divided into four groups. Group A was the sham group (n = 8), Group B the piezoelectric device group (n = 8), Group C the manual saw group (n = 8), and Group D the classical osteotomy group (n = 8). About 3 ml of blood was drawn to compare preoperative and postoperative interleukin-1ß (IL-1ß), thiobarbituric acid-reactive substances (TBARS), tumor necrosis factor-alpha (TNF-alpha), nitric oxide (NO), interleukin-10 (IL-10), and glutathione (GSH) levels. A 1 mm3 piece of soft tissue from the nasal bone of each animal in the study groups was sent for histopathological examination. The Chi-square test was used to analyze the incidence of postoperative necrosis, inflammation, and edema in the groups.
RESULTS: Histopathologically, edema was significantly higher in Group C and Group D compared to Group B. Inflammation was increased in all groups. The necrosis was significantly higher in Group B compared to Group C and Group D. Except for two parameters, no significant changes were found in the biochemical markers for all groups.
CONCLUSIONS: The piezoelectric device was found to be a better option for reducing edema and inflammation, while manual saws and classical osteotomy may lead to more tissue damage.
OBJECTIVE: To investigate the damage to soft tissue and the effects on oxidative stress and proinflammatory cytokines in the blood caused by osteotomy performed on rabbits, using different osteotomy methods. Methods: Thirty-two albino New Zealand rabbits were divided into four groups. Group A was the sham group (n = 8), Group B the piezoelectric device group (n = 8), Group C the manual saw group (n = 8), and Group D the classical osteotomy group (n = 8). About 3 ml of blood was drawn to compare preoperative and postoperative interleukin-1ß (IL-1ß), thiobarbituric acid-reactive substances (TBARS), tumor necrosis factor-alpha (TNF-alpha), nitric oxide (NO), interleukin-10 (IL-10), and glutathione (GSH) levels. A 1 mm3 piece of soft tissue from the nasal bone of each animal in the study groups was sent for histopathological examination. The Chi-square test was used to analyze the incidence of postoperative necrosis, inflammation, and edema in the groups.
RESULTS: Histopathologically, edema was significantly higher in Group C and Group D compared to Group B. Inflammation was increased in all groups. The necrosis was significantly higher in Group B compared to Group C and Group D. Except for two parameters, no significant changes were found in the biochemical markers for all groups.
CONCLUSIONS: The piezoelectric device was found to be a better option for reducing edema and inflammation, while manual saws and classical osteotomy may lead to more tissue damage.
摘要：
背景：鼻成形术是用于鼻美学和病理的常见外科手术。塑造鼻骨是实现成功隆鼻手术的关键步骤。然而,并发症，如出血过多，水肿,粘膜损伤，和骨膜损伤可能发生在截骨术的鼻子塑造。
目的：探讨家兔截骨对软组织的损伤及其对血液中氧化应激和促炎细胞因子的影响。采用不同的截骨方法。方法:32只新西兰白化兔分为4组。A组为假手术组(n=8),B组压电器件组(n=8),C组为手动锯组（n=8），D组为经典截骨组(n=8)。抽取约3毫升血液来比较术前和术后白细胞介素-1β（IL-1β），硫代巴比妥酸反应性物质（TBARS），肿瘤坏死因子-α（TNF-α），一氧化氮（NO），白细胞介素-10（IL-10），和谷胱甘肽（GSH）水平。将来自研究组中每只动物的鼻骨的1mm3软组织块送去进行组织病理学检查。采用卡方检验分析术后坏死的发生率,炎症,和水肿组。
结果：组织病理学，C组和D组的水肿明显高于B组。B组的坏死率明显高于C组和D组。所有组的生化标志物均未发现显著变化.
结论：发现压电装置是减轻水肿和炎症的更好选择，而手动锯和经典截骨术可能会导致更多的组织损伤。
目的：探讨家兔截骨对软组织的损伤及其对血液中氧化应激和促炎细胞因子的影响。采用不同的截骨方法。方法:32只新西兰白化兔分为4组。A组为假手术组(n=8),B组压电器件组(n=8),C组为手动锯组（n=8），D组为经典截骨组(n=8)。抽取约3毫升血液来比较术前和术后白细胞介素-1β（IL-1β），硫代巴比妥酸反应性物质（TBARS），肿瘤坏死因子-α（TNF-α），一氧化氮（NO），白细胞介素-10（IL-10），和谷胱甘肽（GSH）水平。将来自研究组中每只动物的鼻骨的1mm3软组织块送去进行组织病理学检查。采用卡方检验分析术后坏死的发生率,炎症,和水肿组。
结果：组织病理学，C组和D组的水肿明显高于B组。B组的坏死率明显高于C组和D组。所有组的生化标志物均未发现显著变化.
结论：发现压电装置是减轻水肿和炎症的更好选择，而手动锯和经典截骨术可能会导致更多的组织损伤。
