PDF(Pubmed)
Abstract：
BACKGROUND: Serotonin (5-hydroxytryptamine) is a multifunctional bioamine serving as a neurotransmitter, peripheral hormone and mitogen in the vertebrate system. It has pleiotropic activities in central nervous system and gastrointestinal function via an orchestrated action of serotonergic elements, particularly serotonin receptor-mediated signalling cascades. The mitogenic properties of serotonin have garnered recognition for years and have been exploited for repurposing serotonergic-targeted drugs in cancer therapy. However, emerging conflicting findings necessitate a more comprehensive elucidation of serotonin\'s role in cancer pathogenesis.
UNASSIGNED: Here, we provide an overview of the biosynthesis, metabolism and action modes of serotonin. We summarise our current knowledge regarding the effects of the peripheral serotonergic system on tumourigenesis, with a specific emphasis on its immunomodulatory activities in human cancers. We also discuss the dual roles of serotonin in tumour pathogenesis and elucidate the potential of serotonergic drugs, some of which display favourable safety profiles and impressive efficacy in clinical trials, as a promising avenue in cancer treatment.
CONCLUSIONS: Primary synthesis and metabolic routes of peripheral 5-hydroxytryptamine in the gastrointestinal tract. Advanced research has established a strong association between the serotonergic components and carcinogenic mechanisms. The interplay between serotonergic signalling and the immune system within the tumour microenvironment orchestrates antitumour immune responses. Serotonergic-targeted drugs offer valuable clinical options for cancer therapy.
UNASSIGNED: Here, we provide an overview of the biosynthesis, metabolism and action modes of serotonin. We summarise our current knowledge regarding the effects of the peripheral serotonergic system on tumourigenesis, with a specific emphasis on its immunomodulatory activities in human cancers. We also discuss the dual roles of serotonin in tumour pathogenesis and elucidate the potential of serotonergic drugs, some of which display favourable safety profiles and impressive efficacy in clinical trials, as a promising avenue in cancer treatment.
CONCLUSIONS: Primary synthesis and metabolic routes of peripheral 5-hydroxytryptamine in the gastrointestinal tract. Advanced research has established a strong association between the serotonergic components and carcinogenic mechanisms. The interplay between serotonergic signalling and the immune system within the tumour microenvironment orchestrates antitumour immune responses. Serotonergic-targeted drugs offer valuable clinical options for cancer therapy.
摘要：
背景：5-羟色胺（5-羟色胺）是一种多功能的生物胺，用作神经递质，脊椎动物系统中的外周激素和丝裂原。通过5-羟色胺能元素的协调作用，在中枢神经系统和胃肠功能中具有多效活性，特别是5-羟色胺受体介导的信号级联。5-羟色胺的促有丝分裂特性已获得多年的认可，并已被用于在癌症治疗中重新利用5-羟色胺能靶向药物。然而,新出现的相互矛盾的发现需要更全面地阐明5-羟色胺在癌症发病机制中的作用。
■这里，我们提供了生物合成的概述，5-羟色胺的代谢和作用模式。我们总结了我们目前关于外周5-羟色胺能系统对肿瘤发生的影响的知识，特别强调其在人类癌症中的免疫调节活性。我们还讨论了血清素在肿瘤发病机制中的双重作用，并阐明了血清素能药物的潜力，其中一些在临床试验中显示出良好的安全性和令人印象深刻的疗效，作为癌症治疗的一个有希望的途径。
结论：胃肠道外周5-羟色胺的主要合成和代谢途径。先进的研究已经在血清素能成分和致癌机制之间建立了密切的联系。5-羟色胺能信号和肿瘤微环境内的免疫系统之间的相互作用协调抗肿瘤免疫应答。5-羟色胺能靶向药物为癌症治疗提供了有价值的临床选择。
■这里，我们提供了生物合成的概述，5-羟色胺的代谢和作用模式。我们总结了我们目前关于外周5-羟色胺能系统对肿瘤发生的影响的知识，特别强调其在人类癌症中的免疫调节活性。我们还讨论了血清素在肿瘤发病机制中的双重作用，并阐明了血清素能药物的潜力，其中一些在临床试验中显示出良好的安全性和令人印象深刻的疗效，作为癌症治疗的一个有希望的途径。
结论：胃肠道外周5-羟色胺的主要合成和代谢途径。先进的研究已经在血清素能成分和致癌机制之间建立了密切的联系。5-羟色胺能信号和肿瘤微环境内的免疫系统之间的相互作用协调抗肿瘤免疫应答。5-羟色胺能靶向药物为癌症治疗提供了有价值的临床选择。
