Abstract：
Acute kidney injury (AKI) is one of the most common and severe clinical renal syndromes with high morbidity and mortality. Ferroptosis is a form of programmed cell death (PCD), is characterized by iron overload, reactive oxygen species accumulation, and lipid peroxidation. As ferroptosis has been increasingly studied in recent years, it is closely associated with the pathophysiological process of AKI and provides a target for the treatment of AKI. This review offers a comprehensive overview of the regulatory mechanisms of ferroptosis, summarizes its role in various AKI models, and explores its interaction with other forms of cell death, it also presents research on ferroptosis in AKI progression to other diseases. Additionally, the review highlights methods for detecting and assessing AKI through the lens of ferroptosis and describes potential inhibitors of ferroptosis for AKI treatment. Finally, the review presents a perspective on the future of clinical AKI treatment, aiming to stimulate further research on ferroptosis in AKI.
摘要：
急性肾损伤(AKI)是最常见和严重的临床肾脏综合征之一,具有较高的发病率和病死率。Ferroptosis是程序性细胞死亡（PCD）的一种形式，以铁过载为特征，活性氧积累，和脂质过氧化。随着近年来对铁死亡的研究越来越多，与AKI的病理生理过程密切相关,为AKI的治疗提供了靶点。这篇综述提供了铁死亡的调节机制的全面概述，总结了它在各种AKI模型中的作用，并探索其与其他形式的细胞死亡的相互作用，它还介绍了AKI向其他疾病进展中的铁死亡的研究。此外,这篇综述重点介绍了通过铁凋亡透镜检测和评估AKI的方法,并描述了铁凋亡治疗AKI的潜在抑制剂.最后,这篇综述提出了对临床AKI治疗未来的看法，旨在刺激对AKI中铁蛋白的进一步研究。
