Abstract：
An increase of cholesterol concentration within the artery obstructs arterial blood flow once it deposits alongside the arterial wall. This results in atherosclerosis. Carcinogenesis causes a quicker clearance of vascular cholesterol to meet the demands of tumour cell development. Both illnesses have an increased concentration of pro-inflammatory cytokines in the blood. To search the comparative characteristics of cholesterol and pro-inflammatory cytokines in the pathogenesis of atherosclerosis and carcinogenesis, a comprehensive online survey using MEDLINE, Scopus, PubMed, and Google Scholar was conducted for relevant journals with key search term cholesterol and cytokines in atherosclerotic and cancerous patients. According to reports, hypercholesterolaemia related dyslipidemia causes atherosclerosis in blood arteries and hypercholesterolaemia in cell nucleus is a reason for developing carcinogenesis. It is also noted that pro-inflammatory cytokines are involved in both of the aforementioned pathogenesis. Changes in anti-inflammatory cytokines are only the characteristic features of each kind. Thus, Cholesterol and pro-inflammatory cytokines are intensely interlinked in the genesis of atherosclerotic and carcinogenic consequences.
摘要：
一旦胆固醇沉积在动脉壁旁边，动脉内胆固醇浓度的增加就会阻塞动脉血流。这导致动脉粥样硬化。致癌导致血管胆固醇的更快清除以满足肿瘤细胞发育的需要。两种疾病都有血液中促炎细胞因子的浓度增加。探讨胆固醇和促炎细胞因子在动脉粥样硬化和癌变发病中的比较特征。使用MEDLINE进行的全面在线调查，Scopus,PubMed,GoogleScholar在动脉粥样硬化和癌症患者中进行了相关期刊的关键搜索词胆固醇和细胞因子。据报道,与高胆固醇血症相关的血脂异常导致动脉粥样硬化，细胞核中的高胆固醇血症是发生癌变的原因。还注意到促炎细胞因子参与上述两种发病机理。抗炎细胞因子的变化只是每种的特征。因此，胆固醇和促炎细胞因子在动脉粥样硬化和致癌后果的发生中紧密相关。
